Sirpa Jalkanen
Professor of Immunology, Academician
sirjal@utu.fi +358 29 450 4379 +358 40 566 9611 Tykistökatu 6 Turku ORCID-tunniste: https://orcid.org/0000-0002-1922-9732 |
Immunology, inflammation, cancer, drug development, biomarkers
Academician Sirpa Jalkanen is Academy Professor and Professorof Immunology at the Medical Faculty, University of Turku. After her postdoctoral period at Stanford University she has worked in different researcher positions at the University of Turku, Finnish National Institute of Health and Welfare as well as the Academy of Finland. Recently, she has also worked first as a vice chair and then as a chair of the Finnish Academy of Science and Letters. She is the director of the MediCity Research Laboratory (the Research Unit of the Medical Faculty, University of Turku).
The main interest of Sirpa Jalkanen’s research group has been in the mechanisms mediating the cell trafficking in harmful inflammations and cancer. She has published more than 300 peer-reviewed papers and has more than 10 patents. She is an EMBO member and a member of Academia Europae and has received several awards and honours such as Eli Lilly award, Maud Kuistila Prize, Anders Jahre Prize, Äyräpää Prize, Datta Medal, and 2ndEuropean Women Innovator Prize and the Finnish Pharma Industry Prize.
She has also several positions of trust. She is a member of the board in three big Finnish Foundations financing research In addition she is a member of the board of Orion, the biggest pharmaceutical company in Finland and has been a co-founder of two biotech companies.
The overall goal of the research of the Jalkanen group is to elucidate the mechanisms regulating the traffic of leukocytes and cancer cells in the body. The focus is both on blood and lymphatic vasculature. Harmful leukocyte migration into the joints in rheumatoid arthritis and into the pancreas in diabetes are examples of diseases where leukocytes cause extensive destruction. These inflammatory diseases can be cured by inhibiting leukocyte trafficking. Also metastasising malignant cells often use the same mechanisms as leukocytes when extravasating from blood to different organs or migrating via the lymphatics into distant sites. The results obtained can be utilized when new types of drugs are developed to treat harmful inflammations and cancer. The group utilises the most modern imaging techniques, animal models, molecular and cell biology methods including single cell sequencing and mass cytometry and is intimately collaborating with clinicians.
I have been teaching immunology for medical students since 1981. However, my main contribution is to train PhD students and postdoctoral fellows.
- Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis (2021)
- Journal of Neuroinflammation
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Extracellular ATP Limits Homeostatic T Cell Migration Within Lymph Nodes (2021)
- Frontiers in Immunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - First-in-Human Study of 68 Ga-DOTA-Siglec-9, PET Ligand Targeting Vascular Adhesion Protein 1 (2021)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Ga-68-DOTA-Siglec-9, a new positron emission tomography ligand targeting vascular adhesion protein-1 in early rheumatoid arthritis: case report of two patients (2021)
- Scandinavian Journal of Rheumatology
(O2 Muu julkaisu ) - Genome-wide association study of circulating interleukin 6 levels identifies novel loci (2021)
- Human Molecular Genetics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Intravenous Interferon-beta 1a for the Treatment of Ischemia-Reperfusion Injury in Acute Myocardial Infarct in Pigs (2021)
- Heart Surgery Forum
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Lymphatic Endothelial Cell Activation and Dendritic Cell Transmigration Is Modified by Genetic Deletion of Clever-1 (2021)
- Frontiers in Immunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Red blood cell transfusion induces abnormal HIF-1 alpha response to cytokine storm after adult cardiac surgery (2021)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Risky emotional family environment in childhood and depression-related cytokines in adulthood: The protective role of compassion (2021)
- Developmental Psychobiology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Self-Synthesizing Nanorods from Dynamic Combinatorial Libraries against Drug Resistant Cancer (2021)
- Angewandte Chemie International Edition
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Stabilin-1 plays a protective role against Listeria monocytogenes infection through the regulation of cytokine and chemokine production and immune cell recruitment (2021)
- Virulence
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Stage I-IV Colorectal Cancer Prognosis Can Be Predicted by Type and Number of Intratumoral Macrophages and CLEVER-1(+) Vessel Density (2021)
- Cancers
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial (2021)
- Clinical Cancer Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Taipuu vaan ei taitu - koronapandemiasta Suomen kriisinkestävyyden vahvistamiseen (2021) Mauranen Anna, Aro Eva-Mari, Hari Riitta, Jalkanen Sirpa, Kulmala Markku, Mustajoki Arto, Nieminen Risto, Niiniluoto Ilkka, Raivio Kari, Sipilä Jorma, Tirri Kirsi
(D4 Julkaistu kehittämis- tai tutkimusraportti tai -selvitys ) - The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease (2021)
- Obesity
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation (2021)
- Cellular and Molecular Life Sciences
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Vascular Adhesion Protein-1 Determines the Cellular Properties of Endometrial Pericytes (2021)
- Frontiers in cell and developmental biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Vascular Adhesion Protein 1 Mediates Gut Microbial Flagellin-Induced Inflammation, Leukocyte Infiltration, and Hepatic Steatosis (2021)
- Sci
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Why Haven't We Found an Effective Treatment for COVID-19? (2021)
- Frontiers in Immunology
(B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä ) - A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature (2020)
- Frontiers in Cardiovascular Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )