Sirpa Jalkanen
Professor of Immunology, Academician
sirjal@utu.fi +358 29 450 4379 +358 40 566 9611 Tykistökatu 6 Turku ORCID-tunniste: https://orcid.org/0000-0002-1922-9732 |
Immunology, inflammation, cancer, drug development, biomarkers
Academician Sirpa Jalkanen is Academy Professor and Professorof Immunology at the Medical Faculty, University of Turku. After her postdoctoral period at Stanford University she has worked in different researcher positions at the University of Turku, Finnish National Institute of Health and Welfare as well as the Academy of Finland. Recently, she has also worked first as a vice chair and then as a chair of the Finnish Academy of Science and Letters. She is the director of the MediCity Research Laboratory (the Research Unit of the Medical Faculty, University of Turku).
The main interest of Sirpa Jalkanen’s research group has been in the mechanisms mediating the cell trafficking in harmful inflammations and cancer. She has published more than 300 peer-reviewed papers and has more than 10 patents. She is an EMBO member and a member of Academia Europae and has received several awards and honours such as Eli Lilly award, Maud Kuistila Prize, Anders Jahre Prize, Äyräpää Prize, Datta Medal, and 2ndEuropean Women Innovator Prize and the Finnish Pharma Industry Prize.
She has also several positions of trust. She is a member of the board in three big Finnish Foundations financing research In addition she is a member of the board of Orion, the biggest pharmaceutical company in Finland and has been a co-founder of two biotech companies.
The overall goal of the research of the Jalkanen group is to elucidate the mechanisms regulating the traffic of leukocytes and cancer cells in the body. The focus is both on blood and lymphatic vasculature. Harmful leukocyte migration into the joints in rheumatoid arthritis and into the pancreas in diabetes are examples of diseases where leukocytes cause extensive destruction. These inflammatory diseases can be cured by inhibiting leukocyte trafficking. Also metastasising malignant cells often use the same mechanisms as leukocytes when extravasating from blood to different organs or migrating via the lymphatics into distant sites. The results obtained can be utilized when new types of drugs are developed to treat harmful inflammations and cancer. The group utilises the most modern imaging techniques, animal models, molecular and cell biology methods including single cell sequencing and mass cytometry and is intimately collaborating with clinicians.
I have been teaching immunology for medical students since 1981. However, my main contribution is to train PhD students and postdoctoral fellows.
- The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study (2023)
- BMJ medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis (2023)
- Journal of Nuclear Cardiology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A plasma metabolite score of three eicosanoids predicts incident type 2 diabetes: a prospective study in three independent cohorts (2022)
- BMJ open diabetes research and care
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Autoantibodies to Type I Interferons: The Chicken or the Egg? (2022)
- Journal of Interferon and Cytokine Research
(B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä ) - BRAFV600E Expression in Thyrocytes Causes Recruitment of Immunosuppressive STABILIN-1 Macrophages (2022)
- Cancers
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop (2022)
- Cancer Cell
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity (2022)
- Cellular and Molecular Life Sciences
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis (2022)
- BMC Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Effects of altered salt intake and diet on cytokines in humans: A 20-week randomized cross-over intervention study (2022)
- European Journal of Immunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Exploring macrophage mannose receptor expression after myocardial infarction by Al[18F]F-NOTA-DCM positron emission tomography (2022)
- European Heart Journal
(O2 Muu julkaisu ) - [Ga-68]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice (2022)
- Frontiers in Immunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Increased atherosclerotic plaque in AOC3 knock-out in ApoE-/- mice and characterization of AOC3 in atherosclerotic human coronary arteries (2022)
- Frontiers in Cardiovascular Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Nonclinical Characterization of Bexmarilimab, a Clever-1-Targeting Antibody for Supporting Immune Defense Against Cancers (2022)
- Molecular Cancer Therapeutics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Pancreatic cancer survival prediction via inflammatory serum markers (2022)
- Cancer Immunology, Immunotherapy
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Preclinical Evaluation of a Humanized Antibody Against Common Lymphatic Endothelial and Vascular Endothelial Receptor-1, 89Zr-Desferrioxamine-Bexmarilimab, in a Rabbit Model of Renal Fibrosis (2022)
- Journal of Nuclear Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Small-Molecule-based Supramolecular Plastics Mediated by Liquid-Liquid Phase Separation (2022)
- Angewandte Chemie International Edition
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Syövätön Suomi - milloin? (2022)
- InFLAMES Flagship Blog
(E1 Yleistajuinen artikkeli lehdessä) - An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease (2021)
- European Journal of Human Genetics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A prognostic model for colorectal cancer based on CEA and a 48-multiplex serum biomarker panel (2021)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - CD73 contributes to anti-inflammatory properties of afferent lymphatic endothelial cells in humans and mice (2021)
- European Journal of Immunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )