Sirpa Jalkanen
Professor of Immunology, Academician
sirjal@utu.fi +358 29 450 4379 +358 40 566 9611 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-1922-9732(external) |
Immunology, inflammation, cancer, drug development, biomarkers
Academician Sirpa Jalkanen is Academy Professor and Professorof Immunology at the Medical Faculty, University of Turku. After her postdoctoral period at Stanford University she has worked in different researcher positions at the University of Turku, Finnish National Institute of Health and Welfare as well as the Academy of Finland. Recently, she has also worked first as a vice chair and then as a chair of the Finnish Academy of Science and Letters. She is the director of the MediCity Research Laboratory (the Research Unit of the Medical Faculty, University of Turku).
The main interest of Sirpa Jalkanen’s research group has been in the mechanisms mediating the cell trafficking in harmful inflammations and cancer. She has published more than 300 peer-reviewed papers and has more than 10 patents. She is an EMBO member and a member of Academia Europae and has received several awards and honours such as Eli Lilly award, Maud Kuistila Prize, Anders Jahre Prize, Äyräpää Prize, Datta Medal, and 2ndEuropean Women Innovator Prize and the Finnish Pharma Industry Prize.
She has also several positions of trust. She is a member of the board in three big Finnish Foundations financing research In addition she is a member of the board of Orion, the biggest pharmaceutical company in Finland and has been a co-founder of two biotech companies.
The overall goal of the research of the Jalkanen group is to elucidate the mechanisms regulating the traffic of leukocytes and cancer cells in the body. The focus is both on blood and lymphatic vasculature. Harmful leukocyte migration into the joints in rheumatoid arthritis and into the pancreas in diabetes are examples of diseases where leukocytes cause extensive destruction. These inflammatory diseases can be cured by inhibiting leukocyte trafficking. Also metastasising malignant cells often use the same mechanisms as leukocytes when extravasating from blood to different organs or migrating via the lymphatics into distant sites. The results obtained can be utilized when new types of drugs are developed to treat harmful inflammations and cancer. The group utilises the most modern imaging techniques, animal models, molecular and cell biology methods including single cell sequencing and mass cytometry and is intimately collaborating with clinicians.
I have been teaching immunology for medical students since 1981. However, my main contribution is to train PhD students and postdoctoral fellows.
- Immunotherapeutic Blockade of Macrophage Clever-1 Reactivates the CD8(+) T-cell Response against Immunosuppressive Tumors (2019)
- Clinical Cancer Research
(A1 Refereed original research article in a scientific journal) - Kinetic Modelling of [Ga-68]Ga-DOTA-Siglec-9 in Porcine Osteomyelitis and Soft Tissue Infections (2019)
- Molecules
(A1 Refereed original research article in a scientific journal) - Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy (2019)
- American Journal of Human Genetics
(A1 Refereed original research article in a scientific journal) - Prospective multicentre cohort trial on acute appendicitis and microbiota, aetiology and effects of antimicrobial treatment: study protocol for the MAPPAC (Microbiology APPendicitis ACuta) trial (2019)
- BMJ Open
(A1 Refereed original research article in a scientific journal) - Safety Study of Single-Dose Intravenously Administered DOTA-Siglec-9 Peptide in Sprague Dawley Rats (2019)
- International Journal of Toxicology
(A1 Refereed original research article in a scientific journal) - Serum cytokine levels differ according to major cardiovascular risk factors in patients with lower limb atherosclerosis (2019)
- Cytokine
(A1 Refereed original research article in a scientific journal) - Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils (2019)
- Immunity
(A1 Refereed original research article in a scientific journal) - Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage (2019)
- Journal of Molecular Medicine
(A1 Refereed original research article in a scientific journal) - Transcytosis route mediates rapid delivery of intact antibodies to draining lymph nodes (2019)
- Journal of Clinical Investigation
(A1 Refereed original research article in a scientific journal) - Vascular Adhesion Protein-1: A Cell Surface Amine Oxidase in Translation (2019)
- Antioxidants and Redox Signaling
(A2 Refereed review article in a scientific journal ) - Adventures in radiosynthesis of clinical grade [68Ga]Ga-DOTA-Siglec-9 (2018)
- RSC Advances
(A1 Refereed original research article in a scientific journal) - Chronic Active Arthritis Driven by Macrophages Without Involvement of T Cells A Novel Experimental Model of Rheumatoid Arthritis (2018)
- Arthritis and Rheumatology
(A1 Refereed original research article in a scientific journal) - Correlation between increasing tissue ischemia and circulating levels of angiogenic growth factors in peripheral artery disease (2018)
- Cytokine
(A1 Refereed original research article in a scientific journal) - Endothelial cells cope with hypoxia-induced depletion of ATP via activation of cellular purine turnover and phosphotransfer networks (2018)
- BBA - Molecular Basis of Disease
(A1 Refereed original research article in a scientific journal) - Enhanced Antibody Production in Clever-1/Stabilin-1-Deficient Mice (2018)
- Frontiers in Immunology
(A1 Refereed original research article in a scientific journal) - Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice. (2018)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Exploring Alternative Radiolabeling Strategies for Sialic Acid-Binding Immunoglobulin-Like Lectin 9 Peptide: [68Ga]Ga- and [18F]AlF-NOTA-Siglec-9 (2018)
- Molecules
(A1 Refereed original research article in a scientific journal) - Mapping the interaction site and effect of the Siglec-9 inflammatory biomarker on human primary amine oxidase (2018)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Preoperative predictors for systemic inflammatory response in open-heart surgery (2018)
- European Heart Journal
(Other publication) - Regulation of intratumoral purine homeostasis and signaling via concerted action of alkaline phosphatases, CD39 and CD73 (2018)
- Purinergic Signalling
(Other publication)