Sirpa Jalkanen
Professor of Immunology, Academician
sirjal@utu.fi +358 29 450 4379 +358 40 566 9611 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-1922-9732 |
Immunology, inflammation, cancer, drug development, biomarkers
Academician Sirpa Jalkanen is Academy Professor and Professorof Immunology at the Medical Faculty, University of Turku. After her postdoctoral period at Stanford University she has worked in different researcher positions at the University of Turku, Finnish National Institute of Health and Welfare as well as the Academy of Finland. Recently, she has also worked first as a vice chair and then as a chair of the Finnish Academy of Science and Letters. She is the director of the MediCity Research Laboratory (the Research Unit of the Medical Faculty, University of Turku).
The main interest of Sirpa Jalkanen’s research group has been in the mechanisms mediating the cell trafficking in harmful inflammations and cancer. She has published more than 300 peer-reviewed papers and has more than 10 patents. She is an EMBO member and a member of Academia Europae and has received several awards and honours such as Eli Lilly award, Maud Kuistila Prize, Anders Jahre Prize, Äyräpää Prize, Datta Medal, and 2ndEuropean Women Innovator Prize and the Finnish Pharma Industry Prize.
She has also several positions of trust. She is a member of the board in three big Finnish Foundations financing research In addition she is a member of the board of Orion, the biggest pharmaceutical company in Finland and has been a co-founder of two biotech companies.
The overall goal of the research of the Jalkanen group is to elucidate the mechanisms regulating the traffic of leukocytes and cancer cells in the body. The focus is both on blood and lymphatic vasculature. Harmful leukocyte migration into the joints in rheumatoid arthritis and into the pancreas in diabetes are examples of diseases where leukocytes cause extensive destruction. These inflammatory diseases can be cured by inhibiting leukocyte trafficking. Also metastasising malignant cells often use the same mechanisms as leukocytes when extravasating from blood to different organs or migrating via the lymphatics into distant sites. The results obtained can be utilized when new types of drugs are developed to treat harmful inflammations and cancer. The group utilises the most modern imaging techniques, animal models, molecular and cell biology methods including single cell sequencing and mass cytometry and is intimately collaborating with clinicians.
I have been teaching immunology for medical students since 1981. However, my main contribution is to train PhD students and postdoctoral fellows.
- A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature (2020)
- Frontiers in Cardiovascular Medicine
(A1 Refereed original research article in a scientific journal) - Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia (2020)
- Journal of Cell Science
(A1 Refereed original research article in a scientific journal) - Effect of Intravenous Interferon β-1a on Death and Days Free from Mechanical Ventilation among Patients with Moderate to Severe Acute Respiratory Distress Syndrome: A Randomized Clinical Trial (2020)
- JAMA: Journal of the American Medical Association
for the INTEREST Study Group
(A1 Refereed original research article in a scientific journal) - Glucocorticoids inhibit type I IFN beta signaling and the upregulation of CD73 in human lung (2020)
- Intensive Care Medicine
(B1 Non-refereed article in a scientific journal) - Histochemical approach for simultaneous detection of ectonucleotidase and alkaline phosphatase activities in tissues (2020) Purinergic Signaling Karolina Losenkova, Marius Paul, Heikki Irjala, Sirpa Jalkanen, Gennady G. Yegutkin
(A3 Refereed book chapter or chapter in a compilation book) - Human copper-containing amine oxidases in drug design and development (2020)
- Molecules
(A2 Refereed review article in a scientific journal ) - Immunophenotype based on inflammatory cells, PD-1/PD-L1 signalling pathway and M2 macrophages predicts survival in gastric cancer (2020)
- British Journal of Cancer
(A1 Refereed original research article in a scientific journal) - Interferon beta-1a for COVID-19: critical importance of the administration route (2020)
- Critical Care
(B1 Non-refereed article in a scientific journal) - Lymphatic endothelial cells of the lymph node (2020)
- Nature Reviews Immunology
(A2 Refereed review article in a scientific journal ) - New tools to prevent cancer growth and spread: a 'Clever' approach (2020)
- British Journal of Cancer
(A2 Refereed review article in a scientific journal ) - Obesity of mice lacking VAP-1/SSAO byAoc3gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity (2020)
- Journal of Physiology and Biochemistry
(A1 Refereed original research article in a scientific journal) - Patterning of educational attainment across inflammatory markers: Findings from a multi-cohort study (2020)
- Brain, Behavior, and Immunity
(A1 Refereed original research article in a scientific journal) - Prognostic impact of CD73 expression and its relationship to PD-L1 in patients with radically treated pancreatic cancer (2020)
- Virchows Archiv
(A1 Refereed original research article in a scientific journal) - Robo4 contributes to the turnover of Peyer’s patch B cells (2020)
- Mucosal Immunology
(A1 Refereed original research article in a scientific journal) - Single-Cell Transcriptomics of Human Lymph Node Stroma (2020)
- STAR protocols
(B1 Non-refereed article in a scientific journal) - 68Ga-DOTA-E[c(RGDfK)]2 Positron Emission Tomography Imaging of SHARPIN-Regulated Integrin Activity in Mice (2019)
- Journal of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - Cell-type-specific CD73 expression is an independent prognostic factor in bladder cancer (2019)
- Carcinogenesis
(A1 Refereed original research article in a scientific journal) - Clever-1 contributes to lymphocyte entry into the spleen via the red pulp (2019)
- Science Immunology
(A1 Refereed original research article in a scientific journal) - Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats (2019)
- Journal of Neuroinflammation
(A1 Refereed original research article in a scientific journal) - Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns (2019)
- Journal of Medical Genetics
(A1 Refereed original research article in a scientific journal)