Sirpa Jalkanen
Professor of Immunology, Academician
sirjal@utu.fi +358 29 450 4379 +358 40 566 9611 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-1922-9732 |
Immunology, inflammation, cancer, drug development, biomarkers
Academician Sirpa Jalkanen is Academy Professor and Professorof Immunology at the Medical Faculty, University of Turku. After her postdoctoral period at Stanford University she has worked in different researcher positions at the University of Turku, Finnish National Institute of Health and Welfare as well as the Academy of Finland. Recently, she has also worked first as a vice chair and then as a chair of the Finnish Academy of Science and Letters. She is the director of the MediCity Research Laboratory (the Research Unit of the Medical Faculty, University of Turku).
The main interest of Sirpa Jalkanen’s research group has been in the mechanisms mediating the cell trafficking in harmful inflammations and cancer. She has published more than 300 peer-reviewed papers and has more than 10 patents. She is an EMBO member and a member of Academia Europae and has received several awards and honours such as Eli Lilly award, Maud Kuistila Prize, Anders Jahre Prize, Äyräpää Prize, Datta Medal, and 2ndEuropean Women Innovator Prize and the Finnish Pharma Industry Prize.
She has also several positions of trust. She is a member of the board in three big Finnish Foundations financing research In addition she is a member of the board of Orion, the biggest pharmaceutical company in Finland and has been a co-founder of two biotech companies.
The overall goal of the research of the Jalkanen group is to elucidate the mechanisms regulating the traffic of leukocytes and cancer cells in the body. The focus is both on blood and lymphatic vasculature. Harmful leukocyte migration into the joints in rheumatoid arthritis and into the pancreas in diabetes are examples of diseases where leukocytes cause extensive destruction. These inflammatory diseases can be cured by inhibiting leukocyte trafficking. Also metastasising malignant cells often use the same mechanisms as leukocytes when extravasating from blood to different organs or migrating via the lymphatics into distant sites. The results obtained can be utilized when new types of drugs are developed to treat harmful inflammations and cancer. The group utilises the most modern imaging techniques, animal models, molecular and cell biology methods including single cell sequencing and mass cytometry and is intimately collaborating with clinicians.
I have been teaching immunology for medical students since 1981. However, my main contribution is to train PhD students and postdoctoral fellows.
- Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis (2021)
- Journal of Neuroinflammation
(A1 Refereed original research article in a scientific journal) - Extracellular ATP Limits Homeostatic T Cell Migration Within Lymph Nodes (2021)
- Frontiers in Immunology
(A1 Refereed original research article in a scientific journal) - First-in-Human Study of 68 Ga-DOTA-Siglec-9, PET Ligand Targeting Vascular Adhesion Protein 1 (2021)
- Journal of Nuclear Medicine
(A1 Refereed original research article in a scientific journal) - Ga-68-DOTA-Siglec-9, a new positron emission tomography ligand targeting vascular adhesion protein-1 in early rheumatoid arthritis: case report of two patients (2021)
- Scandinavian Journal of Rheumatology
(Other publication) - Genome-wide association study of circulating interleukin 6 levels identifies novel loci (2021)
- Human Molecular Genetics
(A1 Refereed original research article in a scientific journal) - Intravenous Interferon-beta 1a for the Treatment of Ischemia-Reperfusion Injury in Acute Myocardial Infarct in Pigs (2021)
- Heart Surgery Forum
(A1 Refereed original research article in a scientific journal) - Lymphatic Endothelial Cell Activation and Dendritic Cell Transmigration Is Modified by Genetic Deletion of Clever-1 (2021)
- Frontiers in Immunology
(A1 Refereed original research article in a scientific journal) - Red blood cell transfusion induces abnormal HIF-1 alpha response to cytokine storm after adult cardiac surgery (2021)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Risky emotional family environment in childhood and depression-related cytokines in adulthood: The protective role of compassion (2021)
- Developmental Psychobiology
(A1 Refereed original research article in a scientific journal) - Self-Synthesizing Nanorods from Dynamic Combinatorial Libraries against Drug Resistant Cancer (2021)
- Angewandte Chemie International Edition
(A1 Refereed original research article in a scientific journal) - Stabilin-1 plays a protective role against Listeria monocytogenes infection through the regulation of cytokine and chemokine production and immune cell recruitment (2021)
- Virulence
(A1 Refereed original research article in a scientific journal) - Stage I-IV Colorectal Cancer Prognosis Can Be Predicted by Type and Number of Intratumoral Macrophages and CLEVER-1(+) Vessel Density (2021)
- Cancers
(A1 Refereed original research article in a scientific journal) - Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial (2021)
- Clinical Cancer Research
(A1 Refereed original research article in a scientific journal) - Taipuu vaan ei taitu - koronapandemiasta Suomen kriisinkestävyyden vahvistamiseen (2021) Mauranen Anna, Aro Eva-Mari, Hari Riitta, Jalkanen Sirpa, Kulmala Markku, Mustajoki Arto, Nieminen Risto, Niiniluoto Ilkka, Raivio Kari, Sipilä Jorma, Tirri Kirsi
(D4 Published development or research report or study ) - The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease (2021)
- Obesity
(A1 Refereed original research article in a scientific journal) - Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation (2021)
- Cellular and Molecular Life Sciences
(A1 Refereed original research article in a scientific journal) - Vascular Adhesion Protein-1 Determines the Cellular Properties of Endometrial Pericytes (2021)
- Frontiers in cell and developmental biology
(A1 Refereed original research article in a scientific journal) - Vascular Adhesion Protein 1 Mediates Gut Microbial Flagellin-Induced Inflammation, Leukocyte Infiltration, and Hepatic Steatosis (2021)
- Sci
(A1 Refereed original research article in a scientific journal) - Why Haven't We Found an Effective Treatment for COVID-19? (2021)
- Frontiers in Immunology
(B1 Non-refereed article in a scientific journal) - A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature (2020)
- Frontiers in Cardiovascular Medicine
(A1 Refereed original research article in a scientific journal)