Sirpa Jalkanen
Professor of Immunology, Academician
sirjal@utu.fi +358 29 450 4379 +358 40 566 9611 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-1922-9732(external) |
Immunology, inflammation, cancer, drug development, biomarkers
Academician Sirpa Jalkanen is Academy Professor and Professorof Immunology at the Medical Faculty, University of Turku. After her postdoctoral period at Stanford University she has worked in different researcher positions at the University of Turku, Finnish National Institute of Health and Welfare as well as the Academy of Finland. Recently, she has also worked first as a vice chair and then as a chair of the Finnish Academy of Science and Letters. She is the director of the MediCity Research Laboratory (the Research Unit of the Medical Faculty, University of Turku).
The main interest of Sirpa Jalkanen’s research group has been in the mechanisms mediating the cell trafficking in harmful inflammations and cancer. She has published more than 300 peer-reviewed papers and has more than 10 patents. She is an EMBO member and a member of Academia Europae and has received several awards and honours such as Eli Lilly award, Maud Kuistila Prize, Anders Jahre Prize, Äyräpää Prize, Datta Medal, and 2ndEuropean Women Innovator Prize and the Finnish Pharma Industry Prize.
She has also several positions of trust. She is a member of the board in three big Finnish Foundations financing research In addition she is a member of the board of Orion, the biggest pharmaceutical company in Finland and has been a co-founder of two biotech companies.
The overall goal of the research of the Jalkanen group is to elucidate the mechanisms regulating the traffic of leukocytes and cancer cells in the body. The focus is both on blood and lymphatic vasculature. Harmful leukocyte migration into the joints in rheumatoid arthritis and into the pancreas in diabetes are examples of diseases where leukocytes cause extensive destruction. These inflammatory diseases can be cured by inhibiting leukocyte trafficking. Also metastasising malignant cells often use the same mechanisms as leukocytes when extravasating from blood to different organs or migrating via the lymphatics into distant sites. The results obtained can be utilized when new types of drugs are developed to treat harmful inflammations and cancer. The group utilises the most modern imaging techniques, animal models, molecular and cell biology methods including single cell sequencing and mass cytometry and is intimately collaborating with clinicians.
I have been teaching immunology for medical students since 1981. However, my main contribution is to train PhD students and postdoctoral fellows.
- Chronic hypoxia impairs extracellular nucleotide metabolism and barrier function in pulmonary artery vasa vasorum endothelial cells (2011)
- AngiogenesisEuropean Journal of Nuclear Medicine and Molecular Imaging
(A1 Refereed original research article in a scientific journal) - (2011)
- Journal of ImmunologyClinical Physiology and Functional Imaging
(A1 Refereed original research article in a scientific journal) - Different role of CD73 in leukocyte trafficking via blood and lymph vessels (2011)
- Blood
(A1 Refereed original research article in a scientific journal) - Homing-associated molecules CD73 and VAP-1 as targets to prevent harmful inflammations and cancer spread (2011)
- FEBS Letters
(A1 Refereed original research article in a scientific journal) - Identification of Two Imidazole Binding Sites and Key Residues for Substrate Specificity in Human Primary Amine Oxidase AOC3 (2011)
- Biochemistry
(A1 Refereed original research article in a scientific journal) - Ly6C supports preferential homing of central memory CD8(+) T cells into lymph nodes (2011)
- European Journal of ImmunologyEuropean Journal of Immunology
(A1 Refereed original research article in a scientific journal) - Lymphoid organ development, cell trafficking and regulation of lymphocyte responses in primary immunodeficiency diseases (2011) Primary Immunodeficiency Diseases. A Molecular and Cellular Approach Jalkanen Sirpa, Salmi Marko
(A3 Refereed book chapter or chapter in a compilation book) - Mini-PEG spacering of VAP-1-targeting 68Ga-DOTAVAP-P1 peptide improves PET imaging of inflammation. (2011)
- EJNMMI Research
(A1 Refereed original research article in a scientific journal) - Regulation of Mucosal Addressin Cell Adhesion Molecule 1 Expression in Human and Mice by Vascular Adhesion Protein 1 Amine Oxidase Activity (2011)
- Hepatology
(A1 Refereed original research article in a scientific journal) - Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer (2011)
- Blood
(A1 Refereed original research article in a scientific journal) - Stabilin-1/CLEVER-1, a type 2 macrophage marker, is an adhesion and scavenging molecule on human placental macrophages (2011)
- European Journal of Immunology
(A1 Refereed original research article in a scientific journal) - Disordered Lymphoid Purine Metabolism Contributes to the Pathogenesis of Persistent Borrelia garinii Infection in Mice (2010)
- Journal of Immunology
(A1 Refereed original research article in a scientific journal) - Expression of KIT Receptor Tyrosine Kinase in Endothelial Cells of Juvenile Brain Tumors (2010)
- Brain Pathology
(A1 Refereed original research article in a scientific journal) - ”PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide (68) Ga-DOTAVAP-P1: comparison with (18)F-FDG (2010)
- European Journal of Nuclear Medicine and Molecular Imaging
(A1 Refereed original research article in a scientific journal) - PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide Ga-68-DOTAVAP-P1: comparison with F-18-FDG (2010)
(A1 Refereed original research article in a scientific journal) - Preliminary evaluation of novel 68Ga-DOTAVAP-PEG-P2 peptide targeting vascular adhesion protein-1 (2010)
(A1 Refereed original research article in a scientific journal) - Regulation of MAdCAM-1 expression in human hepatic endothelium by VAP-1 amine oxidase activity (2010)
- Hepatology
(A1 Refereed original research article in a scientific journal) - Small-Molecule Inhibitors of Vascular Adhesion Protein-1 Reduce the Accumulation of Myeloid Cells into Tumors and Attenuate Tumor Growth in Mice (2010)
- Journal of Immunology
(A1 Refereed original research article in a scientific journal) - Clever-1/Stabilin-1 regulates lymphocyte migration within lymphatics and leukocyte entrance to sites of inflammation (2009)
(A1 Refereed original research article in a scientific journal) - Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate (2009)
- Blood
(A1 Refereed original research article in a scientific journal)