Arto Pulliainen
principal investigator, PhD
bacteriology; cell biology; bacterial toxins; protein chemistry; drug development
Principal investigator (2015-, University of Turku, Turku, Finland)
Docent / Adjunct professor (2012-, University of Helsinki, Helsinki, Finland)
Post doc (2006-2014, University of Turku, Turku, Finland and Biozentrum, Basel, Switzerland)
PhD (2006, University of Turku, Turku, Finland)
Doctoral student (2001-2006, University of Turku, Turku, Finland)
MSc (2001, University of Oulu, Oulu, Finland)
Turku Cellular Microbiology Laboratory (TCML) studies the interaction of bacterial pathogens with their host cells at molecular level. Our research is focused on proteins, in particular on enzymes, of the bacterial pathogen and of the host cell that are key molecular players shaping the development and severity of an infectious disease. Our goal is to gain detailed molecular knowledge of the protein functions allowing development of targeted pharmaceuticals to prevent and treat infectious diseases.
Funding sources:
Academy of Finland, Novo Nordisk Foundation, Jane and Aatos Erkko Foundation, Sigrid Jusélius Foundation, Finnish Cultural Foundation, The Finnish Society of Sciences and Letters, Jenny and Antti Wihuri Foundation, Emil Aaltonen Foundation, Turku University Foundation, Turku Doctoral Programme of Molecular Medicine (TuDMM), Erasmus+
bacteriology; cell biology; protein chemistry; molecular biology
- The guanine nucleotide exchange factor VAV3 participates in ERBB4-mediated cancer cell migration (2020)
- Journal of Biological Chemistry
- Combination of microbiome analysis and serodiagnostics to assess the risk of pathogen transmission by ticks to humans and animals in central Germany (2019)
- Parasites and Vectors
- Host poly(ADP-ribose) polymerases (PARPs) in acute and chronic bacterial infections (2019)
- Microbes and Infection
- Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin (2018)
- Scientific Reports
- Galectin-3-binding protein: A multitask glycoprotein with innate immunity functions in viral and bacterial infections (2018)
- Journal of Leukocyte Biology
- Microbiome Analysis Reveals the Presence of Bartonella spp. and Acinetobacter spp. in Deer Keds (Lipoptena cervi) (2018)
- Frontiers in Microbiology
- Genome-wide screen of gamma-secretase-mediated intramembrane cleavage of receptor tyrosine kinases (2017)
- Molecular Biology of the Cell
- Molecular Detection of Candidatus Bartonella mayotimonensis in North American Bats (2017)
- Vector-Borne and Zoonotic Diseases
- Molecular Evidence of Chlamydia-Like Organisms in the Feces of Myotis daubentonii Bats (2017)
- Applied and Environmental Microbiology
- Molecular detection of Bartonella spp. in deer ked pupae, adult keds and moose blood in Finland (2015)
- Epidemiology and Infection
- Molecular Detection of Candidatus Bartonella hemsundetiensis in Bats (2015)
- Vector-Borne and Zoonotic Diseases
- Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems (2015)
- mBio
- Bats as reservoir hosts of human bacterial pathogen, Bartonella mayotimonensis (2014)
- Emerging Infectious Diseases
- Cat Scratch Disease Caused by Bartonella grahamii in an Immunocompromised Patient (2013)
- Journal of Clinical Microbiology
- Bacterial effector binds host cell adenylyl cyclase to potentiate G-alfa-s-dependent cAMP production (2012)
- Proceedings of the National Academy of Sciences of the United States of America
- Persistence of Bartonella spp. stealth pathogens: from subclinical infections to vasoproliferative tumor formation (2012)
- FEMS Microbiology Reviews
- Systemic analysis of gene expression profiles identifies ErbB3 as a potential drug target in pediatric alveolar rhabdomyosarcoma (2012)
- PLoS ONE
- Identification of a Novel Streptococcal Adhesin P (SadP) Protein Recognizing Galactosyl-alpha 1-4-galactose-containing Glycoconjugates CONVERGENT EVOLUTION OF BACTERIAL PATHOGENS TO BINDING OF THE SAME HOST RECEPTOR (2011)
- Journal of Biological Chemistry
- Identification of a novel streptococcal adhesin P (SadP) protein recognizing galactosyl-α1-4-galactose-containing glycoconjugates: convergent evolution of bacterial pathogens to binding of the same host receptor (2011) Kouki A, Haataja S, Loimaranta V, Pulliainen AT, Nilsson UJ, Finne J
- Bartonella henselae: Subversion of vascular endothelial cell functions by translocated bacterial effector proteins (2009)
- International Journal of Biochemistry and Cell Biology
