Terhi Heino
University Lecturer, Adjunct professor (docent) in Cell Biology
terhi.j.heino@utu.fi +358 29 450 4027 +358 50 476 5988 Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/0000-0003-2274-6834 |
biomedicine; regenerative medicine; bone tissue; cell biology; stem cells; osteoporosis; fracture healing; osteogenesis; angiogenesis; endothelial cells; wound healing
I got my PhD degree in Cell Biology in 2005 at the Department of Anatomy, Institute of Biomedicine, University of Turku. After my post-doctoral training (Pediatric Endocrinology Unit, Department of Women and Child Health, Karolinska Institutet, Sweden) I returned to my home university and have been working here since 2008. I received the title of a Docent in Cell Biology in 2013.
My current position as a University Lecturer at the Institute of Biomedicine, Faculty of Medicine includes both teaching and research. As part of my profession, I am also promoting sustainable development in medical education. My research interests include stem cells, bone and vascular biology, biomaterials and translational studies in regenerative medicine.
Professionally, my goals are to contribute to human health by providing new scientific knowledge as well as to educate, supervise and tutor undergraduate and graduate students on their way to becoming experts in medicine and biomedical sciences.
My research focuses on elucidating the role of mesenchymal stromal cells (MSC) in bone and vascular biology. We are especially interested in cell-cell and cell-biomaterial interactions and their potential applications in regenerative medicine. We use mainly in vitro cell cultures of human bone marrow derived primary MSCs and peripheral blood derived cells but also utilize cell lines, different biomaterials and clinically relevant patient samples. In summary, our research provides important novel data on cellular interactions and crucial molecular players in angiogenesis and osteogenesis. This contributes to the development of better regenerative medicine applications when aiming to enhance bone and soft tissue healing.
Pedagogic qualification of a teacher, Faculty of Education, University of Turku, Finland, 2009-2014 (60 credits).
More than 10 years of teaching experience both at undergraduate and postgraduate level, including curriculum planning and implementation and development of teaching including several pedagogic approaches.
Primary areas of teaching: Histology, Cell Biology, Anatomy, Pharmacology, Regenerative Medicine and Cancer Biology.
Acting as a mentor (teacher tutor) in Biomedicine BSc program in 2013 -2022.
International teaching experience in Molecular Medicine course for Biomedicine students at Karolinska Institutet, Stockholm, Sweden in 2013-2018.
A partner and mentor in an EU-funded international, multidiciplinary enterpreneurial education project (IDEATE) in 2013-2016.
- Bioactive glasses promote rapid pre-osteoblastic cell migration in contrast to hydroxyapatite, while carbonated apatite shows migration inhibiting properties (2023)
- Scientific Reports
(Refereed journal article or data article (A1)) - Physicochemical and biological characterization of functionalized calcium carbonate (2023)
- Materialia
(Refereed journal article or data article (A1)) - Evidence for the in vivo existence and mobilization of myeloid angiogenic cells and pericyte-like cells in wound patients after skin grafting (2022)
- Wound Repair and Regeneration
(Refereed journal article or data article (A1)) - Mesenchymal cell-derived Wnt1 signaling regulates subchondral bone remodeling but has no effects on the development of growth plate or articular cartilage in mice (2022)
- BONE
(Refereed journal article or data article (A1)) - Physicochemical and biological characterization of silica-coated alumina particles (2022)
- Dental Materials
(Refereed journal article or data article (A1)) - Signature of circulating small non-coding RNAs during early fracture healing in mice (2022)
- Bone Reports
(Refereed journal article or data article (A1)) - Tuki- ja liikuntaelimistön kudosten rakenne ja toiminta (2022) Ortopedia Säämänen Anna-Marja, Heino Terhi, Arokoski Jari, Järvinen Tero, Korhonen Rami
(Article in a professional research book (D2)) - An In Vitro Co-Culture Model of Bone Marrow Mesenchymal Stromal Cells and Peripheral Blood Mononuclear Cells Promotes the Differentiation of Myeloid Angiogenic Cells and Pericyte-Like Cells (2021)
- Stem Cells and Development
(Refereed journal article or data article (A1)) - Multiple targets identified with genome wide profiling of small RNA and mRNA expression are linked to fracture healing in mice (2021)
- Bone Reports
(Refereed journal article or data article (A1)) - Osteoblastic Wnt1 regulates periosteal bone formation in adult mice (2021)
- BONE
(Refereed journal article or data article (A1)) - Structural and elemental characterization of glass and ceramic particles for bone surgery (2021)
- Dental Materials
(Refereed journal article or data article (A1)) - Biomaterial and implant induced ossification: in vitro and in vivo findings (2020)
- Journal of Tissue Engineering and Regenerative Medicine
(Refereed journal article or data article (A1)) - Mesenchymal Stem Cell Therapy for Osteoradionecrosis of the Mandible: a Systematic Review of Preclinical and Human Studies (2020)
- Stem Cell Reviews and Reports
(Refereed review article in scientific journal (A2)) - Angiogenic potential of human mesenchymal stromal cell and circulating mononuclear cell cocultures is reflected in the expression profiles of proangiogenic factors leading to endothelial cell and pericyte differentiation. (2018)
- Journal of Tissue Engineering and Regenerative Medicine
(Refereed journal article or data article (A1)) - Bone Marrow Niche: Role of Different Cells in Bone Metastasis (2018)
- Current Molecular Biology Reports
(Refereed review article in scientific journal (A2)) - Cilia-related protein SPEF2 regulates osteoblast differentiation (2018)
- Scientific Reports
(Refereed journal article or data article (A1)) - Zoledronic acid in vivo increases in vitro proliferation of rat mesenchymal stromal cells (2016)
- Acta Orthopaedica
(Refereed journal article or data article (A1)) - Enhanced osteoblastic differentiation and bone formation in co-culture of human bone marrow mesenchymal stromal cells and peripheral blood mononuclear cells with exogenous VEGF (2015)
- Orthopaedics and Traumatology: Surgery and Research
(Refereed journal article or data article (A1)) - WNT1 Mutations in Early-Onset Osteoporosis and Osteogenesis Imperfecta (2013)
- New England Journal of Medicine
(Refereed journal article or data article (A1)) - Bortezomid is cytotoxic to the human growth plate and permanently impairs bone growth in young mice (2012)
- PLoS ONE
(Refereed journal article or data article (A1))