Lauri Nikkanen
PhD
Cyanobacteria; bioenergetics of photosynthesis; redox regulation in cyanobacteria and in plant chloroplasts; CO2 fixation; protein-protein interactions
- Title of Docent in Plant Biochemistry and Bioenergetics.
- I obtained my MSc degree in Cell and molecular biology at the Department of Biology in University of Turku in 2013
- PhD (with honours) from the Department of Biochemistry in University of Turku in 2018, working at the laboratory of Molecular plant biology under supervision of Prof. Eevi Rintamäki.
- For my PhD thesis, I was awarded the thesis awards from both the Turku Finnish University Society and the University of Turku Doctoral Programme in Molecular Life Sciences.
- In 2018-2023 I was a post-doctoral researcher in the research group led by Yagut Allahverdiyeva, studying the function and regulation of alternative electron transfer pathways of photosynthesis in cyanobacteria.
- I also have a bachelor's degree in International Business and Marketing logistics from Satakunta University of Applied Sciences (2008).
Photosynthetic cyanobacteria are increasingly being used as solar-powered green cell factories for the sustainable production of biofuels and valuable chemicals. Understanding the regulatory mechanisms of photosynthesis is crucial for directing photosynthetic energy towards desired reactions. The electron transport reactions of photosynthesis generate a membrane potential over the thylakoid membrane, the proton motive force, which serves as the driving force for ATP synthesis and regulates protective mechanisms of the photosynthetic machinery. Therefore, the regulation of proton motive force is vital and is achieved by adjusting the proton conductivity of the ATP synthase, as well as by various ion channels and exchangers in the thylakoid membrane. My goal is to investigate these mechanisms in cyanobacteria and find ways to utilize this new knowledge to optimize the productivity of photosynthetic cell factories.
I am the principal investigator (PI) in a project funded by the Academy of Finland titled "Channelling photosynthesis: elucidating regulation of membrane potential in cyanobacteria" (2024-2027).
Always looking for talented students or postdocs to work with, so if you're interested don't hesitate to contact me!
- Flavodiiron proteins associate pH-dependently with the thylakoid membrane for ferredoxin-1-powered O2 photoreduction (2025)
- New Phytologist
(A1 Refereed original research article in a scientific journal) - Glycogen synthesis prevents metabolic imbalance and disruption of photosynthetic electron transport from photosystem II during transition to photomixotrophy in Synechocystis sp PCC 6803 (2024)
- New Phytologist
(A1 Refereed original research article in a scientific journal) - Lighting the way : Compelling open questions in photosynthesis research (2024)
- Plant Cell
(B1 Other refereed article (e.g., editorial, letter, comment) in a scientific journal) - Strong heterologous electron sink outcompetes alternative electron transport pathways in photosynthesis (2024)
- Plant Journal
(A1 Refereed original research article in a scientific journal) - The role of the LysR-type transcription factor PacR in regulating nitrogen metabolism in Anabaena sp. PCC7120 (2024)
- bioRxiv
(Other publication) - Flv3A facilitates O2 photoreduction and affects H2 photoproduction independently of Flv1A in diazotrophic Anabaena filaments (2023)
- New Phytologist
(A1 Refereed original research article in a scientific journal) - Mapping Nanocellulose- and Alginate-Based Photosynthetic Cell Factory Scaffolds: Interlinking Porosity, Wet Strength, and Gas Exchange (2023)
- Biomacromolecules
(A1 Refereed original research article in a scientific journal) - Towards the rate limit of heterologous biotechnological reactions in recombinant cyanobacteria (2023)
- Biotechnology for Biofuels and Bioproducts
(A1 Refereed original research article in a scientific journal) - Editorial: A Novel Perspective for Photosystem I: An Emerging Hub for the Functional Integration of Photosynthesis and Metabolism (2022)
- Frontiers in Plant Science
(B1 Non-refereed article in a scientific journal) - Photosynthetically produced sucrose by immobilized Synechocystis sp. PCC 6803 drives biotransformation in E. coli (2022)
- Biotechnology for Biofuels and Bioproducts
(A1 Refereed original research article in a scientific journal) - Photosynthetic microorganisms as biocatalysts (2021) Photosynthesis: Biotechnological Applications with Microalgae Nikkanen Lauri, Hubacek Michal, Allahverdiyeva Yagut
(A3 Refereed book chapter or chapter in a compilation book) - Regulatory electron transport pathways of photosynthesis in cyanobacteria and microalgae: Recent advances and biotechnological prospects (2021)
- Physiologia Plantarum
(A1 Refereed original research article in a scientific journal) - Cytochrome cM Decreases Photosynthesis under Photomixotrophy in Synechocystis sp. PCC 6803 (2020)
- Plant Physiology
(A1 Refereed original research article in a scientific journal) - Dissecting the interaction of photosynthetic electron transfer with mitochondrial signalling and hypoxic response in the Arabidopsis rcd1 mutant (2020)
- Philosophical Transactions B: Biological Sciences
(A1 Refereed original research article in a scientific journal) - Functional redundancy between flavodiiron proteins and NDH-1 in Synechocystis sp. PCC 6803 (2020)
- Plant Journal
(A1 Refereed original research article in a scientific journal) - Two chloroplast thioredoxin systems differentially modulate photosynthesis in Arabidopsis depending on light intensity and leaf age (2020)
- Plant Journal
(A1 Refereed original research article in a scientific journal) - Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors (2019)
- eLife
(A1 Refereed original research article in a scientific journal) - Chloroplast thioredoxin systems dynamically regulate photosynthesis in plants (2019)
- Biochemical Journal
(A2 Refereed review article in a scientific journal ) - Multilevel regulation of non-photochemical quenching and state transitions by chloroplast NADPH-dependent thioredoxin reductase (2019)
- Physiologia Plantarum
(A1 Refereed original research article in a scientific journal) - Dynamic regulation of photosynthesis by chloroplast thioredoxin systems (2018) Nikkanen Lauri
(G5 Article dissertation )