Professor of Preclinical Imaging and Drug Research Anne Roivainen - UTU Research Portal

Anne Roivainen
Professor of Preclinical Imaging and Drug Research

- Professor,
Turku PET Centre (Independent units)

aroivan@utu.fi

+358 40 824 3510

Kiinamyllynkatu 4-8

Turku

: https://orcid.org/0000-0002-4006-7977

Roivainen Group

Researchgate

Molecular Imaging; PET; Inflammation Imaging

http://inflammation-imaging.utu.fi

Our group is based in Turku PET Centre, University of Turku and Turku University Hospital. Our research focuses on developing radiopharmaceuticals for the PET imaging of various inflammatory diseases.

Inflammation is a significant component of several chronic diseases involving the cardiovascular, metabolic, respiratory, gastro-intestinal, musculoskeletal and nervous systems. Positron emission tomography (PET) with targeted probes enables evaluation of the molecular and cellular pathophysiological mechanisms of diseases (i.e. molecular imaging). However, more specific markers than the currently used glucose analogue, fluorodeoxyglucose 18F-FDG, are needed to assess inflammation and its consequences in different pathologies. Aims of our studies are pre-clinical evaluation of new targeted probes and techniques for molecular imaging of inflammation. The imaging agents will be evaluated in experimental models of inflammation, in healthy subjects and in patients. The main hypothesis is that sensitive whole-body imaging of inflammation will enable early diagnosis, help in patient selection to particular therapy and monitor therapy outcome. Noteworthy, the development of new radiopharmaceuticals requires several years’ effort and expensive proof-of-concept and acute toxicity studies. Our research is focusing on PET tracers and to lesser extent magnetic resonance (MR) and single-photon emission computed tomography (SPECT) imaging agents.

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Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum
cardiomyopathy (2017)
- European Heart JournalIrish Journal of Medical Science
Stapel Britta, Kohlhaas Michael, Ricke-Hoch Melanie, Haghikia Arash, Erschow Sergej, Knuuti Juhani, Silvola Johanna M, Roivainen Anne, Saraste Antti, Nickel Alexander G, Saar Jasmin A, Sieve Irina, Pietzsch Stefan, Müller Mirco, Bogeski Ivan, Kappl Reinhard, Jauhiainen Matti, Thackeray James T, Scherr Michaela, Bengel Frank M, Hagl Christian, Tudorache Igor, Bauersachs Johann, Maack Christoph, Hilfiker-Kleiner Denise
Positron emission tomography tracer [68Ga]NODAGA-Exendin-4 detects glucagon-like peptide-1 receptor expression in mouse atherosclerotic vascular lesions (2017)
- Atherosclerosis
Mia Ståhle, Sanna Hellberg, Jenni Virta, Heidi Liljenbäck, Olli Metsälä, Matti Jauhiainen, Pekka Saukko, Seppo Ylä-Herttuala, Pirjo Nuutila, Juhani Knuuti, Antti Saraste, Anne Roivainen
Pretargeted PET Imaging of trans-Cyclooctene-Modified Porous Silicon NanoparticlesDiffusion weighted imaging of prostate cancer xenografts: comparison of bayesian modeling and independent least squares fitting (2017)
- ACS OmegaInternational Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition. Proceedings
Keinanen O, Makila EM, Lindgren R, Virtanen H, Liljenback H, Oikonen V, Sarparanta M, Molthoff C, Windhorst AD, Roivainen A, Salonen JJ, Airaksinen AJ
Targeting of vascular adhesion protein-1 by positron emission tomography visualizes sites of inflammation in Borrelia burgdorferi-infected mice (2017)
- Arthritis Research and Therapy
Riikka Siitonen, Annukka Pietikäinen, Heidi Liljenbäck, Meeri Käkelä, Mirva Söderström, Sirpa Jalkanen, Jukka Hytönen, Anne Roivainen
18F-Labeling of Mannan for Inflammation Research with Positron Emission Tomography (2016)
- ACS Medicinal Chemistry Letters
Xiang-Guo Li, Cecilia Hagert, Riikka Siitonen, Helena Virtanen, Outi Sareila, Heidi Liljenbäck, Jouni Tuisku, Juhani Knuuti, Jörgen Bergman, Rikard Holmdahl, Anne Roivainen
Age-, sex- and glucose-dependent correlation of plasma soluble vascular adhesion protein-1 concentration with cardiovascular risk factors and subclinical atherosclerosis (2016)
- European Review for Medical and Pharmacological Sciences
Chen DW, Jin Y, Zhao RM, Long LJ, Zhang J, Han CL, Roivainen A, Knuuti J, Jalkanen S, Wang JC.
Cardiac Metabolic Pathway Remodelling in Response to Sunitinib Malate: Potential Role for Positron Emission Tomography in the Cardio-Oncology Setting (conference abstract) (2016)
O’Farrell AC, Evans R, Silvola JMU, Miller IS, Conroy E, Hector S, Cary M, Murray D, Jarzabek MA, Maratha A,
Alamanou M, Mallya Udupi G, Shiels L, Pallaud C, Saraste A, Liljenba¨ck H, Jauhiainen M, Oikonen V, Ducret A, Cutler P, McAuliffe FM, Rousseau JA, Lecomte R, Gascon S, Ky B, Force T, Knuuti J, Gallagher W, Roivainen A, Byrne AT
Comparison of Somatostatin Receptor 2-Targeting PET Tracers in the Detection of Mouse Atherosclerotic PlaquesInfluence of triple disease modifying anti-rheumatic drug therapy on carotid artery inflammation in drug-naive patients with recent onset of rheumatoid arthritis (2016)
- Molecular Imaging and Biology
Petteri Rinne, Sanna Hellberg, Max Kiugel, Jenni Virta, Xiang-Guo Li, Meeri Käkelä, Kerttuli Helariutta, Pauliina Luoto, Heidi Liljenbäck, Harri Hakovirta, Maria Gardberg, Anu J. Airaksinen, Juhani Knuuti, Antti Saraste, Anne Roivainen
(2016)
Parisa Movahedi, Hanne Hakkarainen, Harri Merisaari, Heidi Liljenbäck, Helena Virtanen, Hannu Juhani Aronen, Heikki Minn, Matti Poutanen, Anne Roivainen, Timo Liimatainen, Ivan Jambor
Effect of levosimendan therapy on myocardial infarct size and left ventricular function after acute coronary occlusion (2016)
- HeartScientific Reports
Tarkia M, Stark C, Haavisto M, Kentala R, Vahasilta T, Savunen T, Strandberg M, Saunavaara V, Tolvanen T, Teras M, Pietila M, Nyman L, Duvall E, Saukko P, Levijoki J, Roivainen A, Saraste A, Knuuti J
Erratum to: Absorption, distribution and excretion of intravenously injected 68Ge/68Ga generator eluate in healthy rats, and estimation of human radiation dosimetryMitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism (2016)
- EJNMMI Research
Anu Autio, Helena Virtanen, Tuula Tolvanen, Heidi Liljenbäck, Vesa Oikonen, Tiina Saanijoki, Riikka Siitonen, Meeri Käkelä, Andrea Schüssele, Mika Teräs, Anne Roivainen
Feasibility of 68Ga-labeled Siglec-9 peptide for the imaging of acute lung inflammation: a pilot study in a porcine model of acute respiratory distress syndrome (2016)
- American Journal of Nuclear Medicine and Molecular Imaging
Jaime Retamal, Jens Sörensen, Mark Lubberink, Fernando Suarez-Sipmann, João Batista Borges, Ricardo Feinstein, Sirpa Jalkanen, Gunnar Antoni, Göran Hedenstierna, Anne Roivainen, Anders Larsson, Irina Velikyan
(2016)
- Rheumatology
Haavisto Matti, Saraste Antti, Pirilä Laura, Hannukainen Jarna C, Kalliokoski Kari K, Kirjavainen Anna, Kemppainen Jukka, Möttönen Timo, Knuuti Juhani, Yli-Kerttula Timo, Roivainen Anne
In-Vivo Bone-Targeting of Bis(phosphonate)-Conjugated Double Helical RNA Monitored by Positron Emission Tomography (2016)
- Molecular Pharmaceutics
Satish Jadhav, Meeri Käkelä, Matthieu Bourgery, Kiira Rimpilä, Heidi Liljenbäck, Riikka Siitonen, Jussi Mäkilä, Tiina Laitala-Leinonen, Päivi Poijärvi-Virta, Harri Lönnberg, Anne Roivainen, Pasi Virta
Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaquesSynthesis and In Vivo PET Imaging of Hyaluronan Conjugates of Oligonucleotides (2016)
Silvola JMU, Virtanen H, Siitonen R, Hellberg S, Liljenback H, Metsala O, Stahle M, Saanijoki T, Kakela M, Hakovirta H, Yla-Herttuala S, Saukko P, Jauhiainen M, Veres TZ, Jalkanen S, Knuuti J, Saraste A, Roivainen A
(2016)
- Cell Metabolism
Nikkanen J, Forsstrom S, Euro L, Paetau I, Kohnz RA, Wang LY, Chilov D, Viinamaki J, Roivainen A, Marjamaki P, Liljenback H, Ahola S, Buzkova J, Terzioglu M, Khan NA, Pirnes-Karhu S, Paetau A, Lonnqvist T, Sajantila A, Isohanni P, Tyynismaa H, Nomura DK, Battersby BJ, Velagapudi V, Carroll CJ, Suomalainen A
(2016)
- Research Journal of Pharmaceutical, Biological and Chemical Sciences
Veräjänkorva Esko, Virtanen Helena, Liljenbäck Heidi, Roivainen Anne, Kähäri Veli-Matti
(2016)
- Bioconjugate Chemistry
Satish Jadhav, Meeri Käkelä, Jussi Mäkilä, Max Kiugel, Heidi Liljenbäck, Jenni Virta, Päivi Poijärvi-Virta, Tiina Laitala-Leinonen, Ville Kytö, Sirpa Jalkanen, Antti Saraste, Anne Roivainen, Harri Lönnberg, Pasi Virta
(2016)
- Cardiovascular Diabetology
Hellberg S, Silvola JMU, Kiugel M, Liljenback H, Metsala O, Viljanen T, Metso J, Jauhiainen M, Saukko P, Nuutila P, Yla-Herttuala S, Knuuti J, Roivainen A, Saraste A
USF1 deficiency activates brown adipose tissue and improves cardiometabolic health (2016)
- Science Translational Medicine
Laurila PP, Soronen J, Kooijman S, Forsstrom S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van den Berg SAA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttila J, Makela A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppala I, Lehtimaki T, Erilcsson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PCN, Suomalainen A, Jauhiainenit M