Professor of Preclinical Imaging and Drug Research Anne Roivainen - UTU Research Portal

Anne Roivainen
Professor of Preclinical Imaging and Drug Research

- Professor,
Turku PET Centre (Independent units)

aroivan@utu.fi

+358 40 824 3510

Kiinamyllynkatu 4-8

Turku

: https://orcid.org/0000-0002-4006-7977

Roivainen Group

Researchgate

Molecular Imaging; PET; Inflammation Imaging

http://inflammation-imaging.utu.fi

Our group is based in Turku PET Centre, University of Turku and Turku University Hospital. Our research focuses on developing radiopharmaceuticals for the PET imaging of various inflammatory diseases.

Inflammation is a significant component of several chronic diseases involving the cardiovascular, metabolic, respiratory, gastro-intestinal, musculoskeletal and nervous systems. Positron emission tomography (PET) with targeted probes enables evaluation of the molecular and cellular pathophysiological mechanisms of diseases (i.e. molecular imaging). However, more specific markers than the currently used glucose analogue, fluorodeoxyglucose 18F-FDG, are needed to assess inflammation and its consequences in different pathologies. Aims of our studies are pre-clinical evaluation of new targeted probes and techniques for molecular imaging of inflammation. The imaging agents will be evaluated in experimental models of inflammation, in healthy subjects and in patients. The main hypothesis is that sensitive whole-body imaging of inflammation will enable early diagnosis, help in patient selection to particular therapy and monitor therapy outcome. Noteworthy, the development of new radiopharmaceuticals requires several years’ effort and expensive proof-of-concept and acute toxicity studies. Our research is focusing on PET tracers and to lesser extent magnetic resonance (MR) and single-photon emission computed tomography (SPECT) imaging agents.

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18-kDa translocator protein ligand 18F-FEMPA: Biodistribution and uptake into atherosclerotic plaques in mice (2017)
- Journal of Nuclear Cardiology
Hellberg S, Silvola JM, Kiugel M, Liljenbäck H, Savisto N, Li XG, Thiele A, Lehmann L, Heinrich T, Vollmer S, Hakovirta H, Laine VJ, Ylä-Herttuala S, Knuuti J, Roivainen A, Saraste A.
Accuracy of echocardiographic area-length method in chronic myocardial infarction: comparison with cardiac CT in pigs (2017)
- Cardiovascular Ultrasound
Ballo H, Tarkia M, Haavisto M, Stark C, Strandberg M, Vahasilta T, Saunavaara V, Tolvanen T, Teras M, Hynninen VV, Savunen T, Roivainen A, Knuuti J, Saraste A
A Novel Positron Emission Tomography (PET) Approach to Monitor Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate (2017)
- PLoS ONE
AliceO'Farrell AC, Evans R, Silvola JMU, Miller IS, Conroy E, Hector S, Cary M, Murray DW, Jarzabek MA, Maratha A, Alamanou M, Udupi GM, Shiels L, Pallaud C, Saraste A, Liljenback H, Jauhiainen M, Oikonen V, Ducret A, Cutler P, McAuliffe FM, Rousseau JA, Lecomte R, Gascon S, Arany Z, Ky B, Force T, Knuuti J, Gallagher WM, Roivainen A, Byrne AT, Byrne AT
Comparison of Ga-68-DOTA-Siglec-9 and F-18-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry (2017)
- Contrast Media and Molecular Imaging
Virtanen H, Silvola JMU, Autio A, Li XG, Liljenback H, Hellberg S, Siitonen R, Stahle M, Kakela M, Airaksinen AJ, Helariutta K, Tolvanen T, Veres TZ, Saraste A, Knuuti J, Jalkanen S, Roivainen A, Roivainen A
Effects of atorvastatin and diet interventions on atherosclerotic plaque inflammation and [18F]FDG uptake in Ldlr-/-Apob100100 mice (2017)
- Atherosclerosis
Hellberg S, Sippola S, Liljenback H, Virta J, Silvola JMU, Stahle M, Savisto N, Metso J, Jauhiainen M, Saukko P, Yla-Herttuala S, Nuutila P, Knuuti J, Roivainen A, Saraste A
Exploring the radiosynthesis and in vitro characteristics of [Ga-68]Ga-DOTA-Siglec-9 (2017)
- Journal of Labelled Compounds and Radiopharmaceuticals
Jensen Svend B, Käkelä Meeri, Jodal Lars, Moisio Olli, Alstrup Aage KO, Jalkanen Sirpa, Roivainen Anne
Head-to-Head Comparison of 68Ga-Citrate and 18F-FDG PET/CT for Detection of Infectious Foci in Patients with Staphylococcus aureus Bacteraemia (2017)
- Contrast Media and Molecular Imaging
Salomäki Soile P, Kemppainen Jukka, Hohenthal Ulla, Luoto Pauliina, Eskola Olli, Nuutila Pirjo, Seppänen Marko, Pirilä Laura, Oksi Jarmo, Roivainen Anne
Imaging of αvβ3 integrin expression in experimental myocardial ischemia with [68Ga]NODAGA-RGD positron emission tomography (2017)
- Journal of Translational Medicine
Grönman M, Tarkia M, Kiviniemi T, Halonen P, Kuivanen A, Savunen T, Tolvanen T, Teuho J, Käkelä M, Metsälä O, Pietilä M, Saukko P, Ylä-Herttuala S, Knuuti J, Roivainen A, Saraste A
In Vivo Imaging of Inflammation (2017) Inflammation: from molecular and cellular mechanisms to clinic Roivainen Anne, Saraste Antti
Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum
cardiomyopathy (2017)
- European Heart Journal
Stapel Britta, Kohlhaas Michael, Ricke-Hoch Melanie, Haghikia Arash, Erschow Sergej, Knuuti Juhani, Silvola Johanna M, Roivainen Anne, Saraste Antti, Nickel Alexander G, Saar Jasmin A, Sieve Irina, Pietzsch Stefan, Müller Mirco, Bogeski Ivan, Kappl Reinhard, Jauhiainen Matti, Thackeray James T, Scherr Michaela, Bengel Frank M, Hagl Christian, Tudorache Igor, Bauersachs Johann, Maack Christoph, Hilfiker-Kleiner Denise
Positron emission tomography tracer [68Ga]NODAGA-Exendin-4 detects glucagon-like peptide-1 receptor expression in mouse atherosclerotic vascular lesions (2017)
- Atherosclerosis
Mia Ståhle, Sanna Hellberg, Jenni Virta, Heidi Liljenbäck, Olli Metsälä, Matti Jauhiainen, Pekka Saukko, Seppo Ylä-Herttuala, Pirjo Nuutila, Juhani Knuuti, Antti Saraste, Anne Roivainen
Pretargeted PET Imaging of trans-Cyclooctene-Modified Porous Silicon Nanoparticles (2017)
- ACS Omega
Keinanen O, Makila EM, Lindgren R, Virtanen H, Liljenback H, Oikonen V, Sarparanta M, Molthoff C, Windhorst AD, Roivainen A, Salonen JJ, Airaksinen AJ
Targeting of vascular adhesion protein-1 by positron emission tomography visualizes sites of inflammation in Borrelia burgdorferi-infected mice (2017)
- Arthritis Research and Therapy
Riikka Siitonen, Annukka Pietikäinen, Heidi Liljenbäck, Meeri Käkelä, Mirva Söderström, Sirpa Jalkanen, Jukka Hytönen, Anne Roivainen
18F-Labeling of Mannan for Inflammation Research with Positron Emission Tomography (2016)
- ACS Medicinal Chemistry Letters
Xiang-Guo Li, Cecilia Hagert, Riikka Siitonen, Helena Virtanen, Outi Sareila, Heidi Liljenbäck, Jouni Tuisku, Juhani Knuuti, Jörgen Bergman, Rikard Holmdahl, Anne Roivainen
Age-, sex- and glucose-dependent correlation of plasma soluble vascular adhesion protein-1 concentration with cardiovascular risk factors and subclinical atherosclerosis (2016)
- European Review for Medical and Pharmacological Sciences
Chen DW, Jin Y, Zhao RM, Long LJ, Zhang J, Han CL, Roivainen A, Knuuti J, Jalkanen S, Wang JC.
Cardiac Metabolic Pathway Remodelling in Response to Sunitinib Malate: Potential Role for Positron Emission Tomography in the Cardio-Oncology Setting (conference abstract) (2016)
- Irish Journal of Medical Science
O’Farrell AC, Evans R, Silvola JMU, Miller IS, Conroy E, Hector S, Cary M, Murray D, Jarzabek MA, Maratha A,
Alamanou M, Mallya Udupi G, Shiels L, Pallaud C, Saraste A, Liljenba¨ck H, Jauhiainen M, Oikonen V, Ducret A, Cutler P, McAuliffe FM, Rousseau JA, Lecomte R, Gascon S, Ky B, Force T, Knuuti J, Gallagher W, Roivainen A, Byrne AT
Comparison of Somatostatin Receptor 2-Targeting PET Tracers in the Detection of Mouse Atherosclerotic Plaques (2016)
- Molecular Imaging and Biology
Petteri Rinne, Sanna Hellberg, Max Kiugel, Jenni Virta, Xiang-Guo Li, Meeri Käkelä, Kerttuli Helariutta, Pauliina Luoto, Heidi Liljenbäck, Harri Hakovirta, Maria Gardberg, Anu J. Airaksinen, Juhani Knuuti, Antti Saraste, Anne Roivainen
Diffusion weighted imaging of prostate cancer xenografts: comparison of bayesian modeling and independent least squares fitting (2016)
- International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition. Proceedings
Parisa Movahedi, Hanne Hakkarainen, Harri Merisaari, Heidi Liljenbäck, Helena Virtanen, Hannu Juhani Aronen, Heikki Minn, Matti Poutanen, Anne Roivainen, Timo Liimatainen, Ivan Jambor
Effect of levosimendan therapy on myocardial infarct size and left ventricular function after acute coronary occlusion (2016)
- Heart
Tarkia M, Stark C, Haavisto M, Kentala R, Vahasilta T, Savunen T, Strandberg M, Saunavaara V, Tolvanen T, Teras M, Pietila M, Nyman L, Duvall E, Saukko P, Levijoki J, Roivainen A, Saraste A, Knuuti J
Erratum to: Absorption, distribution and excretion of intravenously injected 68Ge/68Ga generator eluate in healthy rats, and estimation of human radiation dosimetry (2016)
- EJNMMI Research
Anu Autio, Helena Virtanen, Tuula Tolvanen, Heidi Liljenbäck, Vesa Oikonen, Tiina Saanijoki, Riikka Siitonen, Meeri Käkelä, Andrea Schüssele, Mika Teräs, Anne Roivainen