Special Advisor, M.D. , Ph.D., Specialist in Clinical Microbiology Jaana Vuopio - UTU Research Portal

Jaana Vuopio
Special Advisor, M.D. , Ph.D., Specialist in Clinical Microbiology

- Senior Advisor,
Institute of Biomedicine (Faculty of Medicine)

jaana.vuopio@utu.fi

Kiinamyllynkatu 10

Turku

: 7th floor, room 7024

: https://orcid.org/https://orcid.org/0000-0002-0795-4822

• Bacterial infections and asymptomatic carriage caused by beta-hemolytic streptococci, genomic evolution of the bacterium, host susceptibility and risk factors to these infections.
• Molecular epidemiology, surveillance and prevention of spread of antimicrobial resistant bacteria in humans
• Diagnostics and genomic characterization of bacterial pathogens

Bacterial infections cause a significant disease burden in humans. We know that the disease spectrum can vary from asymptomatic carriage to life threatening infections.

Our aim is to gain understanding on reasons why certain individuals develop a disease and the others do not, why pathogens spread and cause epidemics and what could be the means to prevent this from happening. My long standing research interest has also resided in antimicrobial resistance, especially in molecular epidemiology and spread of MRSA, VRE and ESBL-producing Enterobacteriaceae both in health care setting and community.

Our current research areas cover:

Invasive Group A streptococcal disease
Molecular epidemiology and disease burden of Group A streptococcal infections
Molecular epidemiology and spread of MRSA
Surveillance of AMR

Research group members:

Kirsi Gröndahl-Yli-Hannuksela, Ph.D., Adjunct professor, University teacher
Johanna Vilhonen, M.D., Ph.D., specialist in IDs
Tiina Hirvioja, M.D., Ph.D. fellow, specialist in IDs
Jaakko Silvola, M.D., Ph.D. fellow
Ville Kaila, M.D., Ph.D. fellow, specialist in IDs (based at Tampere University Hospital, Tampere)
Erastus Haindongo, M.Sc., Ph.D. fellow (based at University of Namibia, Windhoek)
Laura Lindholm, M.Sc., Ph.D. fellow (based at Finnish Institute of Health and Welfare)

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Faecalibacterium prausnitzii Treatment Improves Hepatic Health and Reduces Adipose Tissue Inflammation in High-fat Fed Mice (2017)
- ISME Journal
Munukka Eveliina, Rintala Anniina, Toivonen Raine, Nylund Matts, Yang Baoru, Takanen Anna, Hänninen Arno, Vuopio Jaana, Huovinen Pentti, Jalkanen Sirpa, Pekkala Satu
Old enemies in new disguises: emergence of Enterococcus faecium as a significant clinical problem at an adult haematology ward (2017)
- Infectious Diseases
Hamalainen S, Pentikainen J, Reijula J, Mauranen E, Koivula I, Lindholm L, Juutilainen A, Nousiainen T, Pyorala M, Vuopio J, Jantunen E
Sequence analysis of pooled bacterial samples enables identification of strain variation in group A streptococcus (2017)
- Scientific Reports
Weldatsadik RG, Wang JW, Puhakainen K, Jiao H, Jalava J, Raisanen K, Datta N, Skoog T, Vuopio J, Jokiranta TS, Kere J
Välikorvatulehdus (lasten äkillinen) - Käypä hoito -suositus (2017)
- Duodecim
Välikorvatulehdus (lasten äkillinen) - Käypä hoito -suositus Heikkinen T, Jero J, Klockars T, Laukkala T, Renko M, Symanen M, Vuopio J
Genomic Characteristics Behind the Spread of Bacteremic Group A Streptococcus Type emm89 in Finland, 2004-2014 (2016)
- Journal of Infectious Diseases
Latronico F, Nasser W, Puhakainen K, Ollgren J, Hyyryläinen HL, Beres SB, Lyytikäinen O, Jalava J, Musser JM, Vuopio J.
Invasive Group A Streptococcal Infections in Children: A Nationwide Survey in Finland (2016)
- Pediatric Infectious Disease Journal
Tapiainen T, Launonen S, Renko M, Saxen H, Salo E, Korppi M, Kainulainen L, Heiskanen-Kosma T, Lindholm L, Vuopio J, Huotari T, Rusanen J, Uhari M
MRSA:n epidemiologia jatkuvassa muutoksessa (2016)
- Lääkärilehti
Olli Likitalo, Outi Lyytikäinen, Laura Lindholm, Jaana Syrjänen, Esa Rintala, Matti Rantanen, Jaana Vuopio
The psoriasis risk allele HLA-Cw0602 shows increased susceptibility to chronic/recurrent tonsillitis and points to shared T cell epitopes in these diseases (2016)
- Scandinavian Journal of Immunology
Haapasalo K, Koskinen L, Suvilehto J, Barker J, Vuopio J, Kere J, Jokiranta S, Saavalainen P
Transcriptome Remodeling Contributes to Epidemic Disease Caused by the Human Pathogen Streptococcus pyogenes (2016)
- mBio
Beres, Kachroo, Nasser, Olsen, Zhu, Flores, de la Riva, Paez-Mayorga, Jimenez, Cantu, Vuopio, Jalava, Kristinsson, Gottfredsson, Corander, Fittipaldi, Di Luca, Petrelli, Vitali, Raiford, Jenkins, Musser
Whole-Genome Sequencing for Routine Pathogen Surveillance in Public Health: a Population Snapshot of Invasive Staphylococcus aureus in Europe (2016)
- mBio
Aanensen DM, Feil EJ, Holden MTG, Dordel J, Yeats CA, Fedosejev A, Goater R, Castillo-Ramirez S, Corander J, Colijn C, Chlebowicz MA, Schouls L, Heck M, Pluister G, Ruimy R, Kahlmeter G, Aring;hman J, Matuschek E, Friedrich AW, Parkhill J, Bentley SD, Spratt BG, Grundmann H; ESCMID Study Group on Molecular Epidemiological Markers (ESGEM); European Staphylococcal Reference Laboratory Working Group
A molecular trigger for intercontinental epidemics of group A Streptococcus (2015)
- Journal of Clinical Investigation
Zhu LC, Olsen RJ, Nasser W, Beres SB, Vuopio J, Kristinsson KG, Gottfredsson M, Porter AR, DeLeo FR, Musser JM
Combined interventions are effective in MRSA control. (2015)
- Infectious Diseases
Elina Jokinen, Janne Laine , Reetta Huttunen, Pertti Arvola, Jaana Vuopio, Laura Lindholm, Risto Vuento, Jaana Syrjänen
Epidemiology and emm types of invasive group A streptococcal infections in Finland, 2008-2013 (2015)
- European Journal of Clinical Microbiology and Infectious Diseases
Smit PW, Lindholm L, Lyytikainen O, Jalava J, Patari-Sampo A, Vuopio J
Evidence of streptococcal origin of acute non-necrotising cellulitis: a serological study. (2015)
- European Journal of Clinical Microbiology and Infectious Diseases
M. Karppelin, T. Siljander, A.-M. Haapala, J. Aittoniemi, R. Huttunen, J. Kere, J. Vuopio, J. Syrjänen
MRSA:n torjunta erilaisia keinoja yhdistämällä on tehokasta (2015)
- Duodecim
Jokinen E, Laine J, Huttunen R, Arvola P, Vuopio J, Lindholm L, Vuento R, Syrjänen J.
Predictors of recurrent cellulitis in five years. Clinical risk factors and the role of PTX3 and CRP (2015)
- Journal of Infection
Karppelin M, Siljander T, Aittoniemi J, Hurme M, Huttunen R, Huhtala H, Kere J, Vuopio J, Syrjänen J
Suomessa käytetään Pohjoismaista eniten mikrobilääkkeitä avohoidossa (2015)
- Lääkärilehti
Tommi Maunuksela, Pentti Huovinen, Jaana Vuopio
European Antibiotic Awareness Day: a five-year perspective of Europe-wide actions to promote prudent use of antibiotics. (2014)
- Eurosurveillance
Earnshaw S, Mancarella G, Mendez A, Todorova B, Magiorakos AP, Possenti E, Stryk M, Gilbro S, Goossens H, Albiger B, Monnet DL; European Antibiotic Awareness Day Technical Advisory Committee; European Antibiotic Awareness Day Collaborative Group.
Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences. (2014)
- Proceedings of the National Academy of Sciences of the United States of America
Waleed Nasser, Stephen B. Beres, Randall J. Olsen, Melissa A. Dean, Kelsey A. Rice, S. Wesley Long, Karl G. Kristinsson, Magnus Gottfredsson, Jaana Vuopio, Kati Raisanen, Dominique A. Caugant, Martin Steinbakk, Donald E. Low, Allison McGeer, Jessica Darenberg, Birgitta Henriques-Normark, Chris A. Van Beneden, Steen Hoffmann, James M. Musser
Origin and evolution of European community-acquired methicillin-resistant Staphylococcus aureus. (2014)
- mBio
Stegger M, Wirth T, Andersen PS, Skov RL, De Grassi A, Simões PM, Tristan A, Petersen A, Aziz M, Kiil K, Cirković I, Udo EE, del Campo R, Vuopio-Varkila J, Ahmad N, Tokajian S, Peters G, Schaumburg F, Olsson-Liljequist B, Givskov M, Driebe EE, Vigh HE, Shittu A, Ramdani-Bougessa N, Rasigade JP, Price LB, Vandenesch F, Larsen AR, Laurent F