Jorma Toppari
MD, PhD
jortop@utu.fi +358 29 450 2826 +358 40 180 2600 Kiinamyllynkatu 10 Turku Työhuone: C5 floor ORCID-tunniste: https://orcid.org/0000-0003-2228-334X |
Lastenendokrinologia; lisääntymisterveys; hormonaaliset haitta-aineet; kives; tyypin 1 diabetes
Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction.
The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.
Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology
- A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals (2016)
- Environmental Health: A Global Access Science Source
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study. (2016)
- JAMA Pediatrics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Class II HLA genotype association with FPIR reflects the islet autoantibody status (2016)
- Scandinavian Journal of Immunology
(O2 Muu julkaisu ) - Compensated reduction in Leydig cell function is associated with lower semen quality variables: a study of 8182 European young men (2016)
- Human Reproduction
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study (2016)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Complete androgen insensitivity syndrome caused by a deep intronic pseudoexon-activating mutation in the androgen receptor gene (2016)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Country-specific chemical signatures of persistent organic pollutants (POPs) in breast milk of French, Danish and Finnish women. (2016)
- Environmental Pollution
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort. (2016)
- Thyroid
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort (2016)
- Clinical Gastroenterology and Hepatology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Exposure Variation and Endocrine Disruption of the Male Reproductive System (2016)
- Hormone Research in Paediatrics
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)
