Jorma Toppari
MD, PhD
jortop@utu.fi +358 29 450 2826 +358 40 180 2600 Kiinamyllynkatu 10 Turku : C5 floor |
Pediatric endocrinology; reproductive health; endocrine disruption; testis; type 1 diabetes
Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction.
The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.
Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology
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- Circulating β cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes (2020)
- Clinical and Experimental Immunology
- Consumption of differently processed milk products in infancy and early childhood and the risk of islet autoimmunity (2020)
- British Journal of Nutrition
- Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study (2020)
- Diabetes Care
- Dynamics of Islet Autoantibodies During Prospective Follow-Up From Birth to Age 15 Years (2020)
- Journal of Clinical Endocrinology and Metabolism
- Early exposure to cats, dogs and farm animals and the risk of childhood asthma and allergy (2020)
- Pediatric Allergy and Immunology
- Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease (2020)
- Environmental Research
- Enhancing and neutralizing anti-coxsackievirus activities in serum samples from patients prior to development of type 1 diabetes (2020)
- Diabetes/Metabolism Research and Reviews
- European Academy of Andrology (EAA) guidelines* on investigation, treatment and monitoring of functional hypogonadism in males (2020)
- Andrology
- European academy of andrology guidelines on Klinefelter Syndrome: Endorsing Organization: European Society of Endocrinology (2020)
- Andrology
- Generation, localization and functions of macrophages during the development of testis (2020)
- Nature Communications
- Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study (2020)
- Diabetes Care
- HLA-DR-DQ haplotypes and specificity of the initial autoantibody in islet specific autoimmunity (2020)
- Pediatric Diabetes
- Hypogonadism and Cryptorchidism (2020)
- Frontiers in Endocrinology
- Lähestyykö tyypin 1 diabeteksen ehkäisy – mitä kertoo DIPP? (2020)
- Lääkärilehti
- Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study (2020)
- Diabetes
- Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies (2020)
- Diabetes
- Maternal Nitrate and Nitrite Intakes during Pregnancy and Risk of Islet Autoimmunity and Type 1 Diabetes: The DIPP Cohort Study (2020)
- Journal of Nutrition
- Metabolic alterations in immune cells associate with progression to type 1 diabetes (2020)
- Diabetologia
- Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: The TEDDY study (2020)
- Gut
- Miehen hedelmällisyys (2020)
- Lääkärilehti
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