MD, PhD Jorma Toppari - UTU Research Portal

Jorma Toppari
MD, PhD

- ,
InFLAMES Flagship (Faculty of Medicine)
- Professor,
Institute of Biomedicine (Faculty of Medicine)

jortop@utu.fi

+358 29 450 2826

+358 40 180 2600

Kiinamyllynkatu 10

Turku

: C5 floor

: https://orcid.org/0000-0003-2228-334X

	Publications J Toppari 2018 Nov.pdf
	CV_Jorma_Toppari_ 2018_Nov.pdf

Pediatric endocrinology; reproductive health; endocrine disruption; testis; type 1 diabetes

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction.

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

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Hypospadias in a cohort of 1072 Danish newborn boys: prevalence and relationship to placental weight, anthropometrical measurements at birth, and reproductive hormone levels at three months of age (2005)
- Journal of Clinical Endocrinology and Metabolism
Boisen KA, Chellakooty M, Schmidt IM, Kai CM, Damgaard IN, Suomi AM, Toppari J, Skakkebaek NE, Main KM
Identification of the leukemia inhibitory factor cell targets within the rat testis (2005)
- Biology of Reproduction
Dorval-Coiffec I, Delcros JG, Hakovirta H, Toppari J, Jégou B, Piquet-Pellorce C
Infantile 4-tert-octylphenol exposure transiently inhibits rat ovarian steroidogenesis and steroidogenic acute regulatory protein (StAR) expression (2005)
- Toxicology and Applied Pharmacology
Myllymäki SA, Karjalainen M, Haavisto TE, Toppari J, Paranko J
In utero and lactational exposure to TCDD; steroidogenic outcomes differ in male and female rat pups (2005)
- Toxicological Sciences
Myllymäki SA, Haavisto TE, Brokken LJ, Viluksela M, Toppari J, Paranko J
In vitro effects of diethylstilbestrol, genistein, 4-tert-butylphenol, and 4-tert-octylphenol on steroidogenic activity of isolated immature rat ovarian follicles (2005)
- Toxicology and Applied Pharmacology
Myllymäki S, Haavisto T, Vainio M, Toppari J, Paranko J
Pattern of orexin expression and direct biological actions of orexin-a in rat testis. (2005)
- Endocrinology
Barreiro ML, Pineda R, Gaytan F, Archanco M, Burrell MA, Castellano JM, Hakovirta H, Nurmio M, Pinilla L, Aguilar E, Toppari J, Dieguez C, Tena-Sempere M.
Prenatal organochlorine pesticides in placentas from Finland: exposure of male infants born during 1997-2001. (2005)
- Placenta
Shen H, Main KM, Kaleva M, Virtanen H, Haavisto AM, Skakkebaek NE, Toppari J, Schramm KW
Relationship between proliferative activity of cancer cells and clinicopathological factors in patients with esophageal squamous cell carcinoma (2005)
- World Journal of Gastroenterology
Huang JX, Yan W, Song ZX, Qian RY, Chen P, Salminen E, Toppari J
Testicular dysgenesis syndrome and the development and occurrence of male reproductive disorders (2005)
- Toxicology and Applied Pharmacology
Virtanen HE, Rajpert-De Meyts E, Main KM, Skakkebaek NE, Toppari J
The regulated expression of c-IAP1 and c-IAP2 during the rat seminiferous epithelial cycle plays a role in the protection of germ cells from Fas-mediated apoptosis (2005)
- Molecular and Cellular Endocrinology
Wang Y, Suominen JS, Parvinen M, Rivero-Muller A, Kiiveri S, Heikinheimo M, Robbins I, Toppari J
Adult 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure and effects on male reproductive organs in three differentially TCDD-susceptible rat lines (2004)
- Toxicological Sciences
Simanainen U, Adamsson A, Tuomisto JT, Miettinen HM, Toppari J, Tuomisto J, Viluksela M
Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: a cross-sectional study of 1,770 young men from the general population in five European countries (2004)
- American Journal of Epidemiology
Jensen TK, Jørgensen N, Punab M, Haugen TB, Suominen J, Zilaitiene B, Horte A, Andersen AG, Carlsen E, Magnus Ø, Matulevicius V, Nermoen I, Vierula M, Keiding N, Toppari J, Skakkebaek NE
Difference in prevalence of congenital cryptorchidism in infants between two Nordic countries (2004)
- Lancet
Boisen KA, Kaleva M, Main KM, Virtanen HE, Haavisto AM, Schmidt IM, Chellakooty M, Damgaard IN, Mau C, Reunanen M, Skakkebaek NE, Toppari J
Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testis (2004)
- Endocrinology
Barreiro ML, Gaytan F, Castellano JM, Suominen JS, Roa J, Gaytan M, Aguilar E, Dieguez C, Toppari J, Tena-Sempere M
[High and increasing prevalence of cryptorchidism in Denmark]. (2004)
- Ugeskrift for Laeger
Boisen KA, Kaleva M, Main KM, Virtanen H, Haavisto AM, Schmidt IM, Chellakooty M, Damgaard IN, Mau C, Reunanen M, Skakkebaek NE, Toppari J
Indirect Sertoli cell-mediated ablation of germ cells in mice expressing the inhibin-alpha promoter/herpes simplex virus thymidine kinase transgene (2004)
- Biology of Reproduction
Ahtiainen M, Toppari J, Poutanen M, Huhtaniemi I
Near-miss apparent SIDS from adrenal crisis (2004)
- Journal of Pediatrics
Gassner HL, Toppari J, Quinteiro González S, Miller WL
Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors (2004)
- Journal of Cell Science
Nogueiras R, Barreiro ML, Caminos JE, Gaytán F, Suominen JS, Navarro VM, Casanueva FF, Aguilar E, Toppari J, Diéguez C, Tena-Sempere M
Orexin 1 receptor messenger ribonucleic acid expression and stimulation of testosterone secretion by orexin-A in rat testis (2004)
- Endocrinology
Barreiro ML, Pineda R, Navarro VM, Lopez M, Suominen JS, Pinilla L, Señaris R, Toppari J, Aguilar E, Diéguez C, Tena-Sempere M
Paracrine regulation of mammalian oocyte maturation and male germ cell survival (2004)
- Proceedings of the National Academy of Sciences of the United States of America
Kawamura K, Kumagai J, Sudo S, Chun SY, Pisarska M, Morita H, Toppari J, Fu P, Wade JD, Bathgate RA, Hsueh AJ