Jorma Toppari
MD, PhD
jortop@utu.fi +358 29 450 2826 +358 40 180 2600 Kiinamyllynkatu 10 Turku : C5 floor |
Pediatric endocrinology; reproductive health; endocrine disruption; testis; type 1 diabetes
Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction.
The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.
Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology
- Adverse trends in male reproductive health: we may have reached a crucial 'tipping point'. (2008)
- International Journal of Andrology
- Concentrations of persistent organochlorine compounds in human milk and placenta are higher in Denmark than in Finland (2008)
- Human Reproduction
- Environmental endocrine disrupters (2008)
- Sexual Development
- Environmental factors and puberty timing: expert panel research needs (2008) Buck Louis GM, Gray LE, Marcus M, Ojeda SR, Pescovitz OH, Witchel SF, Sippell W, Abbott DH, Soto A, Tyl RW, Bourguignon JP, Skakkebaek NE, Swan SH, Golub MS, Wabitsch M, Euling SY, Toppari J
- Epidemiology and pathogenesis of cryptorchidism (2008)
- Human Reproduction Update
- In vivo and in vitro effects of flutamide and diethylstilbestrol on fetal testicular steroidogenesis in the rat (2008)
- Reproductive Toxicology
- Male reproductive health after childhood cancer (2008)
- Acta Paediatrica
- Novel expression and direct effects of adiponectin in the rat testis (2008)
- Endocrinology
- Posterior urethral valves are often associated with cryptorchidism and inguinal hernias (2008)
- Journal of Urology
- Public health implications of altered puberty timing (2008) Golub MS, Collman GW, Foster PM, Kimmel CA, Rajpert-De Meyts E, Reiter EO, Sharpe RM, Skakkebaek NE, Toppari J
- Risk factors for congenital cryptorchidism in a prospective birth cohort study (2008) Damgaard IN, Jensen TK, Jensen TK, Petersen JH, Skakkebaek NE, Toppari J, Main KM
- Sumo-1 function is dispensable in normal mouse development (2008)
- Molecular and Cellular Biology
- Targeted therapy for adrenocortical tumors in transgenic mice through their LH receptor by Hecate-human chorionic gonadotropin beta conjugate (2008)
- Endocrine-Related Cancer
- Cryptorchidism and maternal alcohol consumption during pregnancy (2007)
- Environmental Health Perspectives
- Development and descent of the testis in relation to cryptorchidism (2007)
- Acta Paediatrica
- Expression and localization of androgen receptor-interacting protein-4 in the testis. (2007)
- American Journal of Physiology
- Expression and localization of androgen receptor-interacting protein-4 in the testis (2007)
- American Journal of Physiology : Endocrinology and Metabolism
- Expression of cell cycle-regulatory proteins in patients with esophageal squamous cell carcinoma correlates with tumor aggressiveness (2007) New Research On Esophageal Cancer: Horizons In Cancer Research Huang Jun-Xing, Yan Wei, Song Zheng-Xiang, Qian Rong-Yu, Chen Ping, Salminen Eeva, Toppari Jorma
- Flame retardants in placenta and breast milk and cryptorchidism in newborn boys (2007)
- Environmental Health Perspectives
- From mother to child: investigation of prenatal and postnatal exposure to persistent bioaccumulating toxicants using breast milk and placenta biomonitoring (2007)
- Chemosphere