MD, PhD Jorma Toppari - UTU Research Portal

Jorma Toppari
MD, PhD

- ,
InFLAMES Flagship (Faculty of Medicine)
- Professor,
Institute of Biomedicine (Faculty of Medicine)

jortop@utu.fi

+358 29 450 2826

+358 40 180 2600

Kiinamyllynkatu 10

Turku

: C5 floor

: https://orcid.org/0000-0003-2228-334X

	Publications J Toppari 2018 Nov.pdf
	CV_Jorma_Toppari_ 2018_Nov.pdf

Pediatric endocrinology; reproductive health; endocrine disruption; testis; type 1 diabetes

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction.

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

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Special issue on the Impact of endocrine disrupters on reproductive health (2014)
- Reproduction
Andersson AM, Frederiksen H, Grigor KM, Toppari J, Skakkebæk NE
The methylome of the gut microbiome: disparate Dam methylation patterns in intestinal Bacteroides dorei. (2014)
- Frontiers in microbiology
Leonard MT, Davis-Richardson AG, Ardissone AN, Kemppainen KM, Drew JC, Ilonen J, Knip M, Simell O, Toppari J, Veijola R, Hyöty H, Triplett EW.
Toxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in adult rats (2014)
- PLoS ONE
Viluksela M, Heikkinen P, van der Ven LT, Rendel F, Roos R, Esteban J, Korkalainen M, Lensu S, Miettinen HM, Savolainen K, Sankari S, Lilienthal H, Adamsson A, Toppari J, Herlin M, Finnilä M, Tuukkanen J, Leslie HA, Hamers T, Hamscher G, Al-Anati L, Stenius U, Dervola KS, Bogen IL, Fonnum F, Andersson PL, Schrenk D, Halldin K, Håkansson H.
A cohort effect on serum testosterone levels in Finnish men (2013)
- European Journal of Endocrinology
Perheentupa A, Makinen J, Laatikainen T, Vierula M, Skakkebaek NE, Andersson AM, Toppari J
Association of placenta organotin concentrations with congenital cryptorchidism and reproductive hormone levels in 280 newborn boys from Denmark and Finland (2013)
- Human Reproduction
Rantakokko P, Main KM, Wohlfart-Veje C, Kiviranta H, Airaksinen R, Vartiainen T, Skakkebaek NE, Toppari J, Virtanen HE
Assuring safety without animal testing – The case for the human testis in vitro (2013)
- Reproductive Toxicology
Chapin RE, Boekelheide K, Cortvrindt R, van Duursen MBM, Gant T, Jegou B, Marczylo E, van Pelt AMM, Post JN, Roelofs MJE, Schlatt S, Teerds KJ, Toppari J, Piersma AH
Carcinoma in situ -from clinical observation to a paradigm shift for testicular carcinogenesis (2013)
- International Journal of Developmental Biology
Toppari J
Characterization of the testicular, epididymal and endocrine phenotypes in the Leuven Vdr-deficient mouse model: Targeting estrogen signalling (2013)
- Molecular and Cellular Endocrinology
Jensen MB, Lieben L, Nielsen JE, Willems A, Jorgensen A, Juul A, Toppari J, Carmeliet G, Rajpert-De Meyts E
Evidence for endocrine disruption in humans and wildlife (2013) State of the Science of Endocrine Disrupting Chemicals -2012 Jobling S, Bjerregaard P, Blumberg B, Brandt I, Brian JV, Casey SC, Frouin H, Giudice LC, Heindel JJ, Iguchi T, Kidd KA, Kortenkamp A, Lind M, Ropstad E, Ross PS, Skakkebaek NE, Toppari J, Woodruff TJ, Zoeller RT
Finland is following the trend-sperm quality in Finnish men (2013)
- Asian Journal of Andrology
Virtanen HE, Sadov S, Vierula M, Toppari J
PROKR2 mutations in autosomal recessive Kallmann syndrome (2013)
- Fertility and Sterility
Tommiska J, Toppari J, Vaaralahti K, Kansakoski J, Laitinen EM, Noisa P, Kinnala A, Niinikoski H, Raivio T
Science and policy on endocrine disrupters must not be mixed: a reply to a "common sense" intervention by toxicology journal editors (2013)
- Environmental Health: A Global Access Science Source
Bergman A, Andersson AM, Becher G, van den Berg M, Blumberg B, Bjerregaard P, Bornehag CG, Bornman R, Brandt I, Brian JV, Casey SC, Fowler PA, Frouin H, Giudice LC, Iguchi T, Hass U, Jobling S, Juul A, Kidd KA, Kortenkamp A, Lind M, Martin OV, Muir D, Ochieng R, Olea N, Norrgren L, Ropstad E, Ross PS, Ruden C, Scheringer M, Skakkebaek NE, Soder O, Sonnenschein C, Soto A, Swan S, Toppari J, Tyler CR, Vandenberg LN, Vinggaard AM, Wiberg K, Zoeller RT
Semen quality of 1559 young men from four cities in Japan – a cross-sectional population-based study. (2013)
- BMJ Open
Iwamoto T, Nozawa S, Mieno MN, Yamakawa K, Baba K, Yoshiike M, Namiki M, Koh E, Kanaya J, Okuyama A, Matsumiya K, Tsujimura A, Kanetake H, Eguchi J, Skakkebaek NE, Vierula M, Toppari J, Jørgensen N
Semen quality of 1559 young men from four cities in Japan: a cross-sectional population-based study (2013)
- BMJ Open
Iwamoto T, Nozawa S, Mieno MN, Yamakawa K, Baba K, Yoshiike M, Namiki M, Koh E, Kanaya J, Okuyama A, Matsumiya K, Tsujimura A, Kanetake H, Eguchi J, Skakkebaek NE, Toppari J, Vierula M, Jørgensen N
Semen quality of fertile Japanese men: a cross-sectional population-based study of 792 men (2013)
- BMJ Open
Iwamoto T, Nozawa S, Yoshiike M, Namiki M, Koh E, Kanaya J, Okuyama A, Matsumiya K, Tsujimura A, Komatsu K, Tsukamoto T, Itoh N, Mieno MN, Vierula M, Toppari J, Skakkebaek NE, Jorgensen N
The Impact of Endocrine Disruption – A Consensus Statement on the State of the Science (2013)
- Environmental Health Perspectives
Bergman A, Heindel JJ, Kasten T, Kidd KA, Jobling S, Neira M, Zoeller RT, Becher G, Bjerregaard P, Bornman R, Brandt I, Kortenkamp A, Muir D, Drisse MNB, Ochieng R, Skakkebaek NE, Bylehn AS, Iguchi T, Toppari J, Woodruff TJ
Transgenic GATA-4 expression induces adrenocortical tumorigenesis in C57Bl/6 mice (2013)
- Journal of Cell Science
Chrusciel M, Vuorenoja S, Mohanty B, Rivero-Muller A, Li X, Toppari J, Huhtaniemi I, Rahman NA
A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation (2012)
- Journal of Medical Genetics
Dalgaard MD, Weinhold N, Edsgard D, Silver JD, Pers TH, Nielsen JE, Jorgensen N, Juul A, Gerds TA, Giwercman A, Giwercman YL, Cohn-Cedermark G, Virtanen HE, Toppari J, Daugaard G, Jensen TS, Brunak S, Rajpert-De Meyts E, Skakkebk NE, Leffers H, Gupta R
Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposures (2012)
- International Journal of Andrology
Krysiak-Baltyn K, Toppari J, Skakkebaek NE, Jensen TS, Virtanen HE, Schramm KW, Shen H, Vartiainen T, Kiviranta H, Taboureau O, Audouze K, Brunak S, Main KM
Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta (2012)
- International Journal of Andrology
Virtanen HE, Koskenniemi JJ, Sundqvist E, Main KM, Kiviranta H, Tuomisto JT, Tuomisto J, Viluksela M, Vartiainen T, Skakkebaek NE, Toppari J