MD, PhD Jorma Toppari - UTU Research Portal

Jorma Toppari
MD, PhD

- ,
InFLAMES Flagship (Faculty of Medicine)
- Professor,
Institute of Biomedicine (Faculty of Medicine)

jortop@utu.fi

+358 29 450 2826

+358 40 180 2600

Kiinamyllynkatu 10

Turku

: C5 floor

: https://orcid.org/0000-0003-2228-334X

	Publications J Toppari 2018 Nov.pdf
	CV_Jorma_Toppari_ 2018_Nov.pdf

Pediatric endocrinology; reproductive health; endocrine disruption; testis; type 1 diabetes

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction.

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

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Reply to Eugenio Ventimiglia, Francesco Montorsi, and Andrea Salonia's Letter to the Editor re: Jakob Damsgaard, Ulla N. Joensen, Elisabeth Carlsen, et al. Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2016.06.044. (2017)
- European Urology
Damsgaard J, Joensen UN, Carlsen E, Erenpreiss J, Jensen MB, Matulevicius V, Zilaitiene B, Olesen IA, Perheentupa A, Punab M, Salzbrunn A, Toppari J, Virtanen HE, Juul A, Skakkebæk NE, Jørgensen N
Residual beta-cell function in diabetes children followed and diagnosed in the TEDDY study compared to community controlsSemen quality in the 21st century (2017)
- Pediatric DiabetesNature Reviews Urology
Steck AK, Larsson HE, Liu X, Veijola R, Toppari J, Hagopian WA, Haller MJ, Ahmed S, Akolkar B, Lernmark A, Rewers MJ, Krischer JP; and the TEDDY Study Group
Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study (2017)
- Diabetologia
Lonnrot M, Lynch KF, Larsson HE, Lernmark A, Rewers MJ, Torn C, Burkhardt BR, Briese T, Hagopian WA, She JX, Simell OG, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Hyoty H; on behalf of the TEDDY Study Group
Serum carotenoid and tocopherol concentrations and risk of asthma in childhood: a nested case-control study2017
Virtanen HE, Jorgensen N, Toppari J
(2017)
- Clinical and Experimental Allergy
Hamalainen N, Nwaru BI, Erlund I, Takkinen HM, Ahonen S, Toppari J, Ilonen J, Veijola R, Knip M, Kaila M, Virtanen SM
Spermatogenesis2017Endocrinology of the Testis and Male Reproduction Juho-Antti Mäkelä, Jorma Toppari
Testicular growth and development in puberty (2017)
- Current Opinion in Endocrinology, Diabetes and Obesity
Koskenniemi JJ, Virtanen HE, Toppari J
The association of the HLA-A*24:02, B*39:01 and B*39:06 alleles with type 1 diabetes is restricted to specific HLA-DR/DQ haplotypes in FinnsThe feasibility of salivary sample collection in an international pediatric cohort: The the TEDDY study (2017)
- HLA
Mikk ML, Heikkinen T, El-Amir MI, Kiviniemi M, Laine AP, Harkonen T, Veijola R, Toppari J, Knip M, Ilonen J
(2017)
- Developmental Psychobiology
Roth R, Baxter J, Vehik K, Hopkins D, Killian M, Gesualdo P, Melin J, Simell B, Strauss E, Lernmark A, Johnson SB; The TEDDY Study Group
The Influence of Type 1 Diabetes Genetic Susceptibility Regions, Age, Sex, and Family History on the Progression From Multiple Autoantibodies to Type 1 Diabetes: A TEDDY Study Report (2017)
- Diabetes
Jeffrey P. Krischer, Xiang Liu, Åke Lernmark, William A. Hagopian, Marian J. Rewers, Jin-Xiong She, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar; on behalf of the TEDDY Study Group
Vitamin D intake during the first 4 years and onset of asthma by age 5: A nested case-control study (2017)
- Pediatric Allergy and Immunology
Nwaru B., Hadkhale K., Hämäläinen N., Takkinen H., Ahonen S., Ilonen J., Toppari J., Niemelä O., Haapala A., Veijola R., Knip M., Virtanen S., Nwaru B., Virtanen S.
A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study (2016)
- Scientific Reports
Haghighi M., Johnson S., Qian X., Lynch K., Vehik K., Huang S.; The TEDDY Study Group
A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals (2016)
- Environmental Health: A Global Access Science Source
Vandenberg LN, Agerstrand M, Beronius A, Beausoleil C, Bergman A, Bero LA, Bornehag CG, Boyer CS, Cooper GS, Cotgreave I, Gee D, Grandjean P, Guyton KZ, Hass U, Heindel JJ, Jobling S, Kidd KA, Kortenkamp A, Macleod MR, Martin OV, Norinder U, Scheringer M, Thayer KA, Toppari J, Whaley P, Woodruff TJ, Ruden C
Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study. (2016)
- JAMA Pediatrics
Uusitalo U, Liu X, Yang J, Aronsson CA, Hummel S, Butterworth M, Lernmark Å, Rewers M, Hagopian W, She JX, Simell O, Toppari J, Ziegler AG, Akolkar B, Krischer J, Norris JM, Virtanen SM, TEDDY Study Group.
Class II HLA genotype association with FPIR reflects the islet autoantibody status (2016)
- Scandinavian Journal of Immunology
Koskinen M, Lempainen J, Löyttyniemi E, Mikk ML, Kiviniemi M, Knip M, Veijola R, Toppari J, Ilonen J
Compensated reduction in Leydig cell function is associated with lower semen quality variables: a study of 8182 European young men (2016)
- Human Reproduction
Jorgensen N, Joensen UN, Toppari J, Punab M, Erenpreiss J, Zilaitiene B, Paasch U, Salzbrunn A, Fernandez MF, Virtanen HE, Matulevicius V, Olea N, Jensen TK, Petersen JH, Skakkebaek NE, Andersson AM
Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study (2016)
- Scientific Reports
Torn C, Liu X, Hagopian W, Lernmark A, Simell O, Rewers M, Ziegler AG, Schatz D, Akolkar B, Onengut-Gumuscu S, Chen WM, Toppari J, Mykkanen J, Ilonen J, Rich SS, She JX, Sharma A, Steck A, Krischer J & The TEDDY Study Group
Complete androgen insensitivity syndrome caused by a deep intronic pseudoexon-activating mutation in the androgen receptor gene (2016)
- Scientific Reports
Kansakoski J, Jaaskelainen J, Jaaskelainen T, Tommiska J, Saarinen L, Lehtonen R, Hautaniemi S, Frilander MJ, Palvimo JJ, Toppari J, Raivio T
Country-specific chemical signatures of persistent organic pollutants (POPs) in breast milk of French, Danish and Finnish women. (2016)
- Environmental Pollution
Antignac JP, Main KM, Virtanen HE, Boquien CY, Marchand P, Venisseau A, Guiffard I, Bichon E, Wohlfahrt-Veje C, Legrand A, Boscher C, Skakkebæk NE, Toppari J, Le Bizec B.
Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort. (2016)
- Thyroid
Löf C, Patyra K, Kuulasmaa T, Vangipurapu J, Undeutsch H, Jaeschke H, Pajunen T, Kero A, Krude H, Biebermann H, Kleinau G, Kühnen P, Rantakari K, Miettinen P, Kirjavainen T, Pursiheimo JP, Mustila T, Jääskeläinen J, Ojaniemi M, Toppari J, Ignatius J, Laakso M, Kero J,