Jorma Toppari
MD, PhD
jortop@utu.fi +358 29 450 2826 +358 40 180 2600 Kiinamyllynkatu 10 Turku Office: C5 floor ORCID identifier: https://orcid.org/0000-0003-2228-334X |
Pediatric endocrinology; reproductive health; endocrine disruption; testis; type 1 diabetes
Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction.
The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.
Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology
- Expression of the E3 SUMO-1 ligases PIASx and PIAS1 during spermatogenesis in the rat (2003)
- Gene Expression Patterns
(A1 Refereed original research article in a scientific journal) - Genetics and hormones in testicular descent (2003)
- Hormones (Athens, Greece)
(A1 Refereed original research article in a scientific journal) - Identification of a short PIASx gene promoter that directs male germ cell-specific transcription in vivo (2003)
- Biochemical and Biophysical Research Communications
(A1 Refereed original research article in a scientific journal) - Intercellular organelle traffic through cytoplasmic bridges in early spermatids of the rat: mechanisms of haploid gene product sharing (2003)
- Molecular Biology of the Cell
(A1 Refereed original research article in a scientific journal) - Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism (2003)
- Reproductive BioMedicine Online
(A1 Refereed original research article in a scientific journal) - Overexpression of Bcl-W in the testis disrupts spermatogenesis: revelation of a role of BCL-W in male germ cell cycle control (2003)
- Molecular Endocrinology -Baltimore-
(A1 Refereed original research article in a scientific journal) - Physiology and disorders of testicular descent (2003)
- Endocrine Development
(A2 Refereed review article in a scientific journal ) - Serum androgen bioactivity in cryptorchid and noncryptorchid boys during the postnatal reproductive hormone surge (2003)
- Journal of Clinical Endocrinology and Metabolism
(A1 Refereed original research article in a scientific journal) - Testicular neoplasia in childhood and adolescence (2003)
- Endocrine Development
(A2 Refereed review article in a scientific journal ) - The effects of mono-2-ethylhexyl phathalate, adriamycin and N-ethyl-N-nitrosourea on stage-specific apoptosis and DNA synthesis in the mouse spermatogenesis (2003)
- Toxicology Letters
(A1 Refereed original research article in a scientific journal) - The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis (2003)
- Proceedings of the National Academy of Sciences of the United States of America
(A1 Refereed original research article in a scientific journal) - The role of retinoblastoma protein family in the control of germ cell proliferation, differentiation and survival (2003)
- APMIS
(A2 Refereed review article in a scientific journal ) - The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration (2003)
- Endocrine Reviews
(A2 Refereed review article in a scientific journal ) - Transcription factor GATA-6, cell proliferation, apoptosis, and apoptosis-related proteins Bcl-2 and Bax in human fetal testis (2003)
- Journal of Clinical Endocrinology and Metabolism
(A1 Refereed original research article in a scientific journal) - [Adversive environmental hormones and reproductive health]. (2002) Toppari J
(C2 Editorial work for a scientific compilation book) - Changes in male reproductive health and effects of endocrine disruptors in Scandinavian countries (2002)
- Cadernos de Saúde Pública
(A2 Refereed review article in a scientific journal ) - Developmental expression and spermatogenic stage specificity of transcription factors GATA-1 and GATA-4 and their cofactors FOG-1 and FOG-2 in the mouse testis (2002)
- European Journal of Endocrinology
(A1 Refereed original research article in a scientific journal) - Early postnatal treatment of hypogonadotropic hypogonadism with recombinant human FSH and LH (2002)
- European Journal of Endocrinology
(A1 Refereed original research article in a scientific journal) - East-West gradient in semen quality in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland (2002)
- Human Reproduction
(A1 Refereed original research article in a scientific journal) - Environmental endocrine disrupters and disorders of sexual differentiation (2002)
- Seminars in Reproductive Medicine
(A2 Refereed review article in a scientific journal )