Alex-Mikael Barkoff

Doctoral Researcher, Paediatrics and Adolescent Medicine (Department of Clinical Medicine)
Project Researcher, Institute of Biomedicine (Institute of Biomedicine)

ambark@utu.fi

+358 50 307 5689

Kiinamyllynkatu 10

Turku

Office: Mikro building, 3rd floor, room 354

ORCID identifier: https://orcid.org/0000-0003-0742-1580

Areas of expertise

Pertussis

Research

Serological pertussis studies, Evolution of B. pertussis, ECDC pertussis network projects

Publications

1 of 2

Bordetella pertussis isolates in Finland after acellular vaccination : serotype change and biofilm formation (2024)
- Clinical Microbiology and Infection
Niinikoski Vili, Barkoff Alex-Mikael, Mertsola Jussi, He Qiushui
(Refereed journal article or data article (A1))
Antibody avidity to pertussis toxin after acellular pertussis vaccination and infection (2023)
- Emerging microbes & infections
Knuutila Aapo, Dalby Tine, Ahvenainen Niina, Barkoff Alex-Mikael, Jørgensen Charlotte Sværke, Fuursted Kurt, Mertsola Jussi, He Qiushui
(Refereed journal article or data article (A1))
Automated EuroFlow approach for standardized in-depth dissection of human circulating B-cells and plasma cells (2023)
- Frontiers in Immunology
Delgado Alejandro H., Fluxa Rafael, Perez-Andres Martin, Diks Annieck M., van Gaans van den Brink Jacqueline A. M., Barkoff Alex-Mikael, Blanco Elena, Torres-Valle Alba, Berkowska Magdalena A., Grigore Georgiana, van Dongen J. . J. . M., Orfao Alberto; on behalf of The PERISCOPE Consortium
(Refereed journal article or data article (A1))
Effect of immunization during pregnancy and pre-existing immunity on diphtheria-tetanus-acellular pertussis vaccine responses in infants (2023)
- Emerging microbes & infections
Knuutila Aapo, Barkoff Alex Mikael, Ivaska Lauri, Tenhu Elina, Teräsjärvi Johanna, van Gageldonk Pieter, Buisman Annemarie, Mertsola Jussi, He Qiushui; and PERISCOPE consortium
(Refereed journal article or data article (A1))
Immunogenicity and safety of BPZE1, an intranasal live attenuated pertussis vaccine, versus tetanus-diphtheria- acellular pertussis vaccine: a randomised, double-blind, phase 2b trial (2023)
- Lancet
Keech Cheryl, Miller Vicki E, Rizzardi Barbara, Hoyle Christopher, Pryor Melinda J, Ferrand Jonathan, Solovay Ken, Thalen Marcel, Noviello Stephanie, Goldstein Peter, Gorringe Andrew, Cavell Breeze, He Qiushui, Barkoff Alex-Mikael, Rubin Keith, Locht Camille
(Refereed journal article or data article (A1))
Pastern dermatitis outbreak associated with toxigenic and non-toxigenic Corynebacterium diphtheriae and non-toxigenic Corynebacterium ulcerans at a horse stable in Finland, 2021 (2023)
- Zoonoses and Public Health
Grönthal TSC, Lehto AK, Aarnio SS, Eskola EK, Aimo-Koivisto EM, Karlsson T, Koskinen HI, Barkoff AM, He Q, Lienemann T, Rimhanen-Finne R, Mykkänen A
(Refereed journal article or data article (A1))
Vaccine Antigen Deficiency Does Not Substantially Affect the Identification of Bordetella pertussis Strains by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (2023)
- Journal of Clinical Microbiology
Knuutila Aapo, Harju Inka, Korhonen Suvi, Mäkelä Joonatan, Backström Lucas, Barkoff Alex-Mikael, He Qiushui
(Article or data-article in scientific journal (B1))
Development of a standardized and validated flow cytometry approach for monitoring of innate myeloid immune cells in human blood (2022)
- Frontiers in Immunology
van der Pan Kyra, de Bruin-Versteeg Sandra, Damasceno Daniela, Hernandez-Delgado Alejandro, van der Sluijs-Gelling Alita J, van den Bossche Wouter BL, de Laat Inge F, Diez Paula, Naber Birgitta AE, Diks Annieck M, Berkowska Magdalena A, de Mooij Bas, Groenland Rick J, de Bie Fenna J, Khatri Indu, Kassem Sara, de Jager Anniek L, Louis Alesha, Almeida Julia, van Gaans-van den Brink Jacqueline AM, Barkoff Alex-Mikael, He Qiushui, Ferwerda Gerben, Versteegen Pauline, Berbers Guy AM, Orfao Alberto, van Dongen Jacques JM, Teodosio Cristina
(Refereed journal article or data article (A1))
Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis (2022)
- Science Translational Medicine
Lefrancq Noémie, Bouchez Valérie, Fernandes Nadia, Barkoff Alex-Mikael, Bosch Thijs, Dalby Tine, Åkerlund Thomas, Darenberg Jessica, Fabianova Katerina, Vestrheim Didrik F., Fry Norman K., González-López Juan Jose, Gullsby Karolina, Habington Adele, He Qiushui, Litt David, Martini Helena, Piérard Denis, Stefanelli Paola, Stegger Marc, Zavadilova Jana, Armatys Nathalie, Landier Annie, Guillot Sophie, Hong Samuel L., Lemey Philippe, Parkhill Julian, Toubiana Julie, Cauchemez Simopn, Salje Henrik, Brisse Sylvain
(Refereed journal article or data article (A1))
Macrolide Resistance in Bordetella pertussis: Current Situation and Future Challenges (2022)
- Antibiotics
Ivaska Lauri, Barkoff Alex-Mikael, Mertsola Jussi, He Qiushui
(Refereed review article in scientific journal (A2))
Memory B Cell Activation Induced by Pertussis Booster Vaccination in Four Age Groups of Three Countries (2022)
- Frontiers in Immunology
Versteegen Pauline, Barkoff Alex-Mikael, Valente Pinto Marta, Van De Kasteele Jan, Knuutila Aapo, Bibi Sagida, De Rond Lia, Teräsjärvi Johanna, Sanders Katherine, De Zeeuw-Brouwer Mary-lene, Luoto Raakel, Ten Hulscher Hinke, Clutterbuck Elizabeth A., Sanders Elisabeth A. M., Mertsola Jussi, Berbers Guy A. M., He Qiushui, Kelly Dominic F., Buisman Anne-Marie; PERISCOPE Consortium
(Refereed journal article or data article (A1))
Pertussis toxin neutralizing antibody response after an acellular booster vaccination in Dutch and Finnish participants of different age groups (2022)
- Emerging microbes & infections
Knuutila Aapo, Versteegen Pauline, Barkoff Alex-Mikael, van Gageldonk Pieter, Mertsola Jussi, Berbers Guy, He Qiushui; PERISCOPE Consortium
(Refereed journal article or data article (A1))
Whole blood based point-of-care assay for the detection of anti-pertussis toxin IgG antibodies (2022)
- Journal of Immunological Methods
Knuutila Aapo, Rautanen Carita, Barkoff Alex-Mikael, Mertsola Jussi, He Qiushui
(Refereed journal article or data article (A1))
Circulation of pertussis and poor protection against diphtheria among middle-aged adults in 18 European countries (2021)
- Nature Communications
Berbers Guy, van Gageldonk Pieter, van de Kassteele Jan, Wiedermann Ursula, Desombere Isabelle, Dalby Tine, Toubiana Julie, Tsiodras Sotirios, Ferencz Ildikó Paluska, Mullan Kathryn, Griskevicius Algirdas, Kolupajeva Tatjana, Vestrheim Didrik Frimann, Palminha Paula, Popovici Odette, Wehlin Lena, Kastrin Tamara, Maďarová Lucia, Campbell Helen, Ködmön Csaba, Bacci Sabrina, Barkoff Alex-Mikael, He Qiushui; Serosurveillance Study Team
(Refereed journal article or data article (A1))
Evaluation of Anti-PT Antibody Response after Pertussis Vaccination and Infection: The Importance of Both Quantity and Quality (2021)
- Toxins
Barkoff Alex-Mikael, Knuutila Aapo, Mertsola Jussi, He Qiushui
(Refereed review article in scientific journal (A2))
IL17Frs763780 single nucleotide polymorphism is associated with asthma after bronchiolitis in infancy (2021)
- Acta Paediatrica
Holster Annukka, Teräsjärvi Johanna, Barkoff Alex-Mikael, Lauhkonen Eero, Törmanen Sari, Helminen Merja, Korppi Matti, He Qiushui, Nuolivirta Kirsi
(Refereed journal article or data article (A1))
Pertussis seroprevalence among adults of reproductive age (20-39 years) in fourteen European countries (2021)
- APMIS
Wehlin Lena, Ljungman Margaretha, Kühlmann-Berenzon Sharon, Galanis Ilias, Huygen Kris, Pierard Denis, Dalby Tine, Petridou Evi, Molnár Zsuzsanna, Carollo Maria, Ausiello Clara M., Lipnickiene Vilnele, Haider Julie, Aase Audun, Herstad Tove Karin, Rastawicki Waldemar, Rio Carla, Popovici Odette, Manchon Fernando De Ory, Bacci Sabrina, Barkoff Alex-Mikael, Hänninen Arno, He Qiushui, Hallander Hans
(Refereed journal article or data article (A1))
Responses to an acellular pertussis booster vaccination in children, adolescents, and young and older adults: A collaborative study in Finland, the Netherlands, and the United Kingdom (2021)
- EBioMedicine
Versteegen Pauline, Valente Pinto Marta, Barkoff Alex M., van Gageldonk Pieter G.M., Kassteele Jan.v.d., van Houten Marlies A., Sanders Elisabeth A.M., de Groot Ronald, Diavatopoulos Dimitri A., Bibi Sagida, Luoto Raakel, He Qiushui, Buisman Anne-Marie, Kelly Dominic F., Mertsola Jussi, Berbers Guy A.M.
(Refereed journal article or data article (A1))
Simultaneous Determination of Antibodies to Pertussis Toxin and Adenylate Cyclase Toxin Improves Serological Diagnosis of Pertussis (2021)
- Diagnostics
Knuutila Aapo, Barkoff Alex M, Mertsola Jussi, Osicka Radim, Sebo Peter, He Qiushui
(Refereed journal article or data article (A1))
Widespread circulation of pertussis in Finland during 1968-1972 when the whole cell vaccine was in use (2021)
- Clinical Microbiology and Infection
Ahvenainen Niina, Dub Timothee, Knuutila Aapo, Barkoff Alex M, Sane Jussi, He Quishui
(Article or data-article in scientific journal (B1))