Refereed review article in scientific journal (A2)

Clinical significance of tumor-stroma ratio in head and neck cancer: a systematic review and meta-analysis




List of AuthorsAlmangush Alhadi, Alabi Rasheed Omobolaji, Troiano Giuseppe, Coletta Ricardo D, Salo Tuula, Pirinen Matti, Mäkitie Antti A, Leivo Ilmo

PublisherBioMed Central Ltd.

Publication year2021

JournalBMC Cancer

Journal name in sourceBMC cancer

Journal acronymBMC Cancer

Article number480

Volume number21

ISSN1471-2407

eISSN1471-2407

DOIhttp://dx.doi.org/10.1186/s12885-021-08222-8

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/56239476


Abstract
The clinical significance of tumor-stroma ratio (TSR) has been examined in many tumors. Here we systematically reviewed all studies that evaluated TSR in head and neck cancer.
Four databases (Scopus, Medline, PubMed and Web of Science) were searched using the term tumo(u)r-stroma ratio. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were followed.
TSR was studied in nine studies of different subsites (including cohorts of nasopharyngeal, oral, laryngeal and pharyngeal carcinomas). In all studies, TSR was evaluated using hematoxylin and eosin staining. Classifying tumors based on TSR seems to allow for identification of high-risk cases. In oral cancer, specifically, our meta-analysis showed that TSR is significantly associated with both cancer-related mortality (HR 2.10, 95%CI 1.56-2.84) and disease-free survival (HR 1.84, 95%CI 1.38-2.46).
The assessment of TSR has a promising prognostic value and can be implemented with minimum efforts in routine head and neck pathology.

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Last updated on 2022-19-12 at 15:54