Refereed journal article or data article (A1)

A prognostic model for colorectal cancer based on CEA and a 48-multiplex serum biomarker panel




List of AuthorsBjörkman Kajsa, Jalkanen Sirpa, Salmi Marko, Mustonen Harri, Kaprio Tuomas, Kekki Henna, Pettersson Kim, Böckelman Camilla, Haglund Caj

PublisherNATURE RESEARCH

Publication year2021

JournalScientific Reports

Journal name in sourceSCIENTIFIC REPORTS

Journal acronymSCI REP-UK

Article numberARTN 4287

Volume number11

Issue number1

Number of pages9

ISSN2045-2322

DOIhttp://dx.doi.org/10.1038/s41598-020-80785-1

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/53697638


Abstract
Mortality in colorectal cancer (CRC) remains high, resulting in 860,000 deaths annually. Carcinoembryonic antigen is widely used in clinics for CRC patient follow-up, despite carrying a limited prognostic value. Thus, an obvious need exists for multivariate prognostic models. We analyzed 48 biomarkers using a multiplex immunoassay panel in preoperative serum samples from 328 CRC patients who underwent surgery at Helsinki University Hospital between 1998 and 2003. We performed a multivariate prognostic forward-stepping background model based on basic clinicopathological data, and a multivariate machine-learned prognostic model based on clinicopathological data and biomarker variables, calculating the disease-free survival using the value of importance score. From the 48 analyzed biomarkers, only IL-8 emerged as a significant prognostic factor for CRC patients in univariate analysis (HR 4.88; 95% CI 2.00-11.92; p = 0.024) after correcting for multiple comparisons. We also developed a multivariate model based on all 48 biomarkers using a random survival forest analysis. Variable selection based on a minimal depth and the value of importance yielded two tentative candidate CRC prognostic markers: IL-2Ra and IL-8. A multivariate prognostic model using machine-learning technologies improves the prognostic assessment of survival among surgically treated CRC patients.

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Last updated on 2022-07-04 at 18:29