Refereed journal article or data article (A1)

Aberrant mesolimbic dopamine-opiate interaction in obesity



List of Authors: Tuominen L, Tuulari J, Karlsson H, Hirvonen J, Helin S, Salminen P, Parkkola R, Hietala J, Nuutila P, Nummenmaa L

Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE

Publication year: 2015

Journal: NeuroImage

Journal name in source: NEUROIMAGE

Journal acronym: NEUROIMAGE

Volume number: 122

Start page: 80

End page: 86

Number of pages: 7

ISSN: 1053-8119

DOI: http://dx.doi.org/10.1016/j.neuroimage.2015.08.001


Abstract

The study demonstrates a link between DRD2 and MOR availabilities in living human brain. This interaction is selectively disrupted in mesolimbic dopamine system in morbid obesity. We propose that interaction between the dopamine and opioid systems is a prerequisite for normal reward processing and that disrupted cross-talk may underlie altered reward processing in obesity. (C) 2015 Elsevier Inc. All rights reserved.


Last updated on 2021-24-06 at 08:12