A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Impact of polyols on Oral microbiome of Estonian schoolchildren
Tekijät: Stsepetova J, Truu J, Runnel R, Nommela R, Saag M, Olak J, Nolvak H, Preem JK, Oopkaup K, Krjutskov K, Honkala E, Honkala S, Makinen K, Makinen PL, Vahlberg T, Vermeiren J, Bosscher D, de Cock P, Mandar R, Mandar R
Kustantaja: BMC
Julkaisuvuosi: 2019
Journal: BMC Oral Health
Tietokannassa oleva lehden nimi: BMC ORAL HEALTH
Lehden akronyymi: BMC ORAL HEALTH
Artikkelin numero: ARTN 60
Vuosikerta: 19
Sivujen määrä: 10
ISSN: 1472-6831
DOI: https://doi.org/10.1186/s12903-019-0747-z
Verkko-osoite: https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-019-0747-z
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/40281772
BackgroundOral microbiome has significant impact on both oral and general health. Polyols have been promoted as sugar substitutes in prevention of oral diseases. We aimed to reveal the effect of candies containing erythritol, xylitol or control (sorbitol) on salivary microbiome.MethodsNinety children (11.30.6years) consumed candies during 3years. Microbial communities were profiled using Illumina HiSeq 2000 sequencing and real-time PCR.ResultsThe dominant phyla in saliva were Firmicutes (39.1%), Proteobacteria (26.1%), Bacteroidetes (14.7%), Actinobacteria (12%) and Fusobacteria (6%). The microbiome of erythritol group significantly differed from that of the other groups. Both erythritol and xylitol reduced the number of observed bacterial phylotypes in comparison to the control group. The relative abundance of the genera Veillonella, Streptococcus and Fusobacterium were higher while that of Bergeyella lower after erythritol intervention when comparing with control. The lowest prevalence of caries-related mutans streptococci corresponded with the lowest clinical caries markers in the erythritol group.ConclusionsDaily consumption of erythritol, xylitol or control candies has a specific influence on the salivary microbiome composition in schoolchildren. Erythritol is associated with the lowest prevalence of caries-related mutans streptococci and the lowest levels of clinical caries experience.Trial registration p id=Par5 ClinicalTrials.gov Identifier NCT01062633.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
