A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Fabrication of a multifunctional nano-in-micro drug delivery platform by microfluidic templated encapsulation of porous silicon in polymer matrix
Tekijät: Hongbo Zhang, Dongfei Liu, Mohammad-Ali Shahbazi, Ermei Mäkilä, Bárbara Herranz-Blanco, Jarno Salonen, Jouni Hirvonen, Hélder A. Santos
Kustantaja: Wiley-VCH Verlag
Julkaisuvuosi: 2014
Journal: Advanced Materials
Tietokannassa oleva lehden nimi: Advanced Materials
Vuosikerta: 26
Numero: 26
Aloitussivu: 4497
Lopetussivu: 4503
Sivujen määrä: 8
ISSN: 1521-4095
DOI: https://doi.org/10.1002/adma.201400953
Verkko-osoite: http://api.elsevier.com/content/abstract/scopus_id:84904188661
A multifunctional nano-in-micro drug delivery platform is developed by conjugating the porous silicon nanoparticles with mucoadhesive polymers and subsequent encapsulation into a pH-responsive polymer using microfluidics. The multistage platform shows monodisperse size distribution and pH-responsive payload release, and the released nanoparticles are mucoadhesive. Moreover, this platform is capable of simultaneously loading and releasing multidrugs with distinct properties. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
