A1 Journal article – refereed
Fabrication of a multifunctional nano-in-micro drug delivery platform by microfluidic templated encapsulation of porous silicon in polymer matrix




List of Authors: Hongbo Zhang, Dongfei Liu, Mohammad-Ali Shahbazi, Ermei Mäkilä, Bárbara Herranz-Blanco, Jarno Salonen, Jouni Hirvonen, Hélder A. Santos
Publisher: Wiley-VCH Verlag
Publication year: 2014
Journal: Advanced Materials
Journal name in source: Advanced Materials
Volume number: 26
Issue number: 26
ISSN: 1521-4095

Abstract


A multifunctional nano-in-micro drug delivery platform is developed by conjugating the porous silicon nanoparticles with mucoadhesive polymers and subsequent encapsulation into a pH-responsive polymer using microfluidics. The multistage platform shows monodisperse size distribution and pH-responsive payload release, and the released nanoparticles are mucoadhesive. Moreover, this platform is capable of simultaneously loading and releasing multidrugs with distinct properties. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.



Last updated on 2019-20-07 at 16:45