A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Synthesis of an Alkyne-Modified Bleomycin Disaccharide Precursor, Conversion to a F-18-Labeled Radiotracer, and Preliminary in vivo-PET Imaging Studies




TekijätSajal K. Maity, Cheng-Bin Yim, Satish Jadhav, Alejandra Verhassel, Johanna Tuomela, Olof Solin, Tove J. Grönroos, Pasi Virta

KustantajaWILEY-V C H VERLAG GMBH

Julkaisuvuosi2019

JournalEuropean Journal of Organic Chemistry

Tietokannassa oleva lehden nimiEUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Lehden akronyymiEUR J ORG CHEM

Vuosikerta2019

Numero1

Aloitussivu156

Lopetussivu163

Sivujen määrä8

ISSN1434-193X

eISSN1099-0690

DOIhttps://doi.org/10.1002/ejoc.201801488

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/39298097


Tiivistelmä
The bleomycins (BLMs) are known antitumor antibiotics composed of the tumoricidal and tumor seeking domains. The peptide structure of BLMs is responsible for the cytotoxicity by selective oxidative cleavage of DNA (and RNA), while the tumor cell selectivity and internalization resides in the disaccharide moiety (i.e. BLM disaccharide). This has prompted researchers to utilize BLM disaccharide and its derivatives as constituents for the selective recognition of tumor cells, which may find further applications as new tumor imaging tools or drug delivery vehicles. In the present study a high yielding synthesis of an alkyne modified BLM disaccharide precursor that may be used as a useful agent for the click conjugation, its conversion to a F-18-labeled radiotracer, and preliminary in vivo PET imaging studies of the tracer with breast cancer (MCF-7) xenograft mouse models are described.

Ladattava julkaisu

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.





Last updated on 2024-26-11 at 18:52