A1 Refereed original research article in a scientific journal
Bioavailability of docosahexaenoic acid 22:6(n-3) from enantiopure triacylglycerols and their regioisomeric counterpart in rats
Authors: Linderborg Kaisa M., Kulkarni Amruta, Zhao Ai, Zhang Jian, Kallio Heikki, Magnusson Johann D., Haraldsson Gudmundur G., Zhang Yumei, Yang Baoru
Publication year: 2019
Journal: Food Chemistry
Journal name in source: Food chemistry
Journal acronym: Food Chem
Volume: 283
First page : 381
Last page: 389
Number of pages: 9
ISSN: 0308-8146
eISSN: 1873-7072
DOI: https://doi.org/10.1016/j.foodchem.2018.12.130
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/39151018
Lack of synthetic enantiospecific triacylglycerols (TAGs) has hindered our understanding of the impact of TAG structure on the absorption and metabolic fate of fatty acids (FAs). In a five-day feeding trial with mildly (n-3) deficient rats, the bioavailability of docosahexaenoic acid [22:6(n-3), DHA] and stearic acid (18:0) from the two different enantiomers of TAG: sn-22:6(n-3)-18:0-18:0 and sn-18:0-18:0-22:6(n-3), and their regioisomeric TAG: sn-18:0-22:6(n-3)-18:0 was compared. Less secretion of fecal DHA was detected from the sn-2 position compared with the sn-1 and sn-3 positions, but no difference was found in DHA content of the fasting plasma or in the weight of the body or organs. 18:0 was lost to feces mainly as cleaved from the primary positions but also as glycerol-bound. The 5-day intervention in rats was long enough to modify the fatty acid profile of plasma phospholipids.
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