A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Long-term outcomes following minimally invasive and open esophagectomy in Finland: A population-based study




Julkaisun tekijät: Eero Sihvo, Olli Helminen, Jarmo Gunn, Jussi O.T. Sipilä, Päivi Rautava, Ville Kytö
Kustantaja: Academic Press
Julkaisuvuosi: 2018
Journal: EJSO - European Journal of Surgical Oncology
Tietokannassa oleva lehden nimi: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Lehden akronyymi: Eur J Surg Oncol
ISSN: 0748-7983
eISSN: 1532-2157

Tiivistelmä
Background
Studies of long-term survival after minimally invasive and open esophagectomy are needed. The aim of this study was to compare long-term outcomes following minimally invasive and open esophagectomy for esophageal cancer at the population level.
Methods
All patients undergoing minimally invasive (n = 159) or open transthoracic (n = 431) esophagectomy for esophageal cancer in Finland between 2004 and 2014 were identified from nationwide registries. Propensity score matching was used to create groups of 150 minimally invasive and open esophagectomies with balanced baseline characteristics (sex, age, comorbidity, center volume, year of surgery, histology, stage (local or locally advanced), and neoadjuvant therapy). The primary outcome was 1-year survival after surgery. Secondary outcomes were the 3-year, 5-year, and 90-day survival.
Results
The propensity matched 1-year survival rate was 85.3% after minimally invasive and 74.7% after open esophagectomy (adjusted HR 0.53, 95% CI 0.31–0.89; P = 0.0174). At 3 years, those were 68.7% and 55.6% (adjusted HR 0.62; 95% CI 0.43–0.91; P = 0.0144), respectively; at 5 years, survival rates were 61.8% and 51.9% (adjusted HR 0.68, 95% CI 0.47–0.97; P = 0.0347). The 30- and 90-day survival rates after minimally invasive and open surgery were 99.3% vs. 98.0% and 97.3% vs. 92.0%, respectively, without statistical significance.
Conclusions
In this population-based propensity matched study, minimally invasive esophagectomy was associated with improved long-term survival. Due to multiple confounding factors replication studies are needed.

Last updated on 2019-21-08 at 20:11