A2 Review article in a scientific journal
Pesticides and oncogenic modulation




List of Authors: Vakonaki E, Androutsopoulos VP, Liesivuori J, Tsatsakis AM, Spandidos DA
Publisher: Elsevier
Publication year: 2013
Journal: Toxicology
Journal acronym: Toxicology
Number in series: May
Volume number: 307
Issue number: May
Number of pages: 4
ISSN: 0300-483X

Abstract

Pesticides constitute a diverse class of chemicals used for the protection of agricultural products. Several lines of evidence demonstrate that organochlorine and organophosphate pesticides can cause malignant transformation of cells in in vitro and in vivo models. In the current minireview a comprehensive summary of recent in vitro findings is presented along with data reported from human population studies, regarding the impact of pesticide exposure on activation or dysregulation of oncogenes and tumor suppressor genes. Substantial mechanistic work suggests that pesticides are capable of inducing mutations in oncogenes and increase their transcriptional expression in vitro, whereas human population studies indicate associations between pesticide exposure levels and mutation occurrence in cancer-related genes. Further work is required to fully explore the exact mechanisms by which pesticide exposure affects the integrity and normal function of oncogenes and tumor suppressor genes in human populations.




Internal Authors/Editors

Last updated on 2019-21-08 at 20:27