Refereed review article in scientific journal (A2)
Integrin trafficking in cells and tissues
List of Authors: Paulina Moreno-Layseca, Jaroslav Icha, Hellyeh Hamidi, Johanna Ivaska
Publication year: 2019
Journal: Nature Cell Biology
Journal name in source: Nature cell biology
Journal acronym: Nat Cell Biol
Volume number: 21
Issue number: 2
Start page: 122
End page: 132
Number of pages: 11
ISSN: 1465-7392
eISSN: 1476-4679
DOI: http://dx.doi.org/10.1038/s41556-018-0223-z
Abstract
Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is accomplished primarily through the integrin family of cell-surface receptors. Integrins are internalized and enter the endocytic-exocytic pathway before being recycled back to the plasma membrane. The trafficking of this extensive protein family is regulated in multiple context-dependent ways to modulate integrin function in the cell. Here, we discuss recent advances in understanding the mechanisms and cellular roles of integrin endocytic trafficking.
Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is accomplished primarily through the integrin family of cell-surface receptors. Integrins are internalized and enter the endocytic-exocytic pathway before being recycled back to the plasma membrane. The trafficking of this extensive protein family is regulated in multiple context-dependent ways to modulate integrin function in the cell. Here, we discuss recent advances in understanding the mechanisms and cellular roles of integrin endocytic trafficking.
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