A2 Review article in a scientific journal
Integrin trafficking in cells and tissues

List of Authors: Paulina Moreno-Layseca, Jaroslav Icha, Hellyeh Hamidi, Johanna Ivaska
Publication year: 2019
Journal: Nature Cell Biology
Journal name in source: Nature cell biology
Journal acronym: Nat Cell Biol
Volume number: 21
ISSN: 1465-7392
eISSN: 1476-4679

Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is accomplished primarily through the integrin family of cell-surface receptors. Integrins are internalized and enter the endocytic-exocytic pathway before being recycled back to the plasma membrane. The trafficking of this extensive protein family is regulated in multiple context-dependent ways to modulate integrin function in the cell. Here, we discuss recent advances in understanding the mechanisms and cellular roles of integrin endocytic trafficking.

Last updated on 2019-20-07 at 10:50