A2 Review article in a scientific journal
Hydrolytic Reactions of Nucleoside Phosphoramidates: Kinetics and Mechanisms




List of Authors: Lonnberg T, Ora M, Lonnberg H
Publisher: BENTHAM SCIENCE PUBL LTD
Publication year: 2010
Journal: Mini-Reviews in Organic Chemistry
Journal name in source: MINI-REVIEWS IN ORGANIC CHEMISTRY
Journal acronym: MINI-REV ORG CHEM
Number in series: 1
Volume number: 7
Issue number: 1
Number of pages: 11
ISSN: 1570-193X

Abstract
Nucleoside phosphoramidates have recently received considerable interest as pro-drugs of antiviral analogs of nucleoside monophosphates and as constituents of antisense oligonucleotides. For these reasons, the hydrolytic stability of phosphoramidate linkages also is of interest. The present paper gives a survey of the kinetic and mechanistic studies with phosphoramidates, above all the studies with nucleoside phosphoramidates.


Research Areas


Last updated on 2019-21-08 at 21:51