A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
2,6-Dimercuriphenol as a Bifacial Dinuclear Organometallic Nucleobase
Tekijät: Ukale Dattatraya, Lönnberg Tuomas
Kustantaja: Wiley - V C H Verlag GmbH & Co. KGaA
Julkaisuvuosi: 2018
Journal: Angewandte Chemie International Edition
Vuosikerta: 57
Numero: 49
Aloitussivu: 16171
Lopetussivu: 16175
Sivujen määrä: 5
ISSN: 1433-7851
eISSN: 1521-3773
DOI: https://doi.org/10.1002/anie.201809398
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/36856765
A C-nucleoside having 2,6-dimercuriphenol as the base moiety has been synthesized and incorporated into an oligonucleotide. NMR and UV melting experiments revealed the ability of this bifacial organometallic nucleobase surrogate to form stable dinuclear HgII-mediated base triples with adenine, cytosine, and thymine (or uracil) in solution as well as within a triple-helical oligonucleotide. A single HgII-mediated base triple between 2,6-dimercuriphenol and two thymines increased both Hoogsteen and Watson–Crickmelting temperatures of a 15-mer pyrimidine·purine*pyrimidine triple helix by more than 10 oC relative to an unmodified triple helix of the same length. This novel binding mode could be exploited in targeting certain pathogenic nucleic acids as well as in DNA nanotechnology.
Ladattava julkaisu This is an electronic reprint of the original article. |