Refereed journal article or data article (A1)
Long non-coding RNA PICSAR decreases adhesion and promotes migration of squamous carcinoma cells by downregulating α2β1 and α5β1 integrin expression
List of Authors: Minna Piipponen, Jyrki Heino, Veli-Matti Kähäri, Liisa Nissinen
Publisher: The Company of Biologists
Publication year: 2018
Journal: Biology Open
Article number: bio037044
Volume number: 7
Issue number: 11
Number of pages: 8
ISSN: 2046-6390
eISSN: 2046-6390
DOI: http://dx.doi.org/10.1242/bio.037044
URL: http://bio.biologists.org/content/7/11/bio037044
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/36512953
Long non-coding RNAs (lncRNAs) regulate various cellular processes, and
they have emerged as potential biomarkers and therapeutic targets in
cancer. We have previously characterized the oncogenic role of lncRNA
PICSAR (p38 inhibited cutaneous squamous cell carcinoma associated
lincRNA) in cutaneous squamous cell carcinoma (cSCC), the most common
metastatic skin cancer. In this study, we show that knockdown of PICSAR
in cSCC cells upregulates expression of α2, α5 and β1 integrins,
resulting in increased cell adhesion and decreased cell migration on
collagen I and fibronectin. In contrast, overexpression of PICSAR in
cSCC cells downregulates expression of α2, α5 and β1 integrins on cell
surface, resulting in decreased cell adhesion on collagen I and
fibronectin and increased cell migration. These results demonstrate a
novel mechanism for regulation of the expression of collagen and
fibronectin binding integrins by lncRNA PICSAR, leading to altered
adhesion and migration of cSCC cells.
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