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Use of Bone Turnover Markers in Osteoporosis




TekijätLenora J, Ivaska KK, Gerdhem P

KustantajaSPRINGER

Julkaisuvuosi2010

JournalClinical Reviews in Bone and Mineral Metabolism

Tietokannassa oleva lehden nimiCLINICAL REVIEWS IN BONE AND MINERAL METABOLISM

Lehden akronyymiCLIN REV BONE MINER

Vuosikerta8

Aloitussivu1

Lopetussivu14

Sivujen määrä14

ISSN1534-8644

eISSN1559-0119

DOIhttps://doi.org/10.1007/s12018-009-9042-x


Tiivistelmä
Bone metabolism can be assessed by measuring bone turnover markers in serum or urine. Bone turnover markers are substances released from bone during bone turnover. They can be skeletal tissue proteins, collagen fragments, peptides, or enzymes released from bone cells. Bone turnover markers are extensively used in research applications but also as tools for the management of skeletal disorders in clinical practice. Osteoporosis-related applications may include assessment of response to, or deciding on osteoporosis therapy; identification of individuals with increased bone loss, and prediction of risk for fragility fractures. Advancements in the development of assays to measure bone markers has made the measurements available also for clinical practice. The possibility to use them in various aspects of clinical practice has been tested in the recent years and given promising results. Monitoring the efficacy of bone-active drugs is currently the most promising application for bone turnover markers. Some markers, particularly resorption markers may also be useful in identifying individuals who are at high risk for bone loss and future fracture. In this article we discuss some potential applications of currently available bone turnover markers in postmenopausal osteoporosis.



Last updated on 2024-26-11 at 20:44