A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

3-Tesla Magnetic Resonance Angiographic Assessment of a Tissue-Engineered Small-Caliber Vascular Graft Implanted in a Rat




TekijätYamanami M, Yamamoto A, Iida H, Watanabe T, Kanda K, Yaku H, Nakayama Y

KustantajaWILEY-LISS

Julkaisuvuosi2010

JournalJournal of Biomedical Materials Research Part B: Applied Biomaterials

Tietokannassa oleva lehden nimiJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Lehden akronyymiJ BIOMED MATER RES B

Vuosikerta92B

Numero1

Aloitussivu156

Lopetussivu160

Sivujen määrä5

ISSN1552-4973

DOIhttps://doi.org/10.1002/jbm.b.31501


Tiivistelmä
In the development of small-caliber vascular grafts (diameter; less than 3 mm), animal implantation studies have been mostly performed by using rat abdominal aortas, and their certain patency must evaluate with sacrificing every observation periods, which is both labor-intensive and time-consuming when performing a large number of experiments. This study is the first to demonstrate the application of 3-Tesla contrast-free time-of-flight magnetic resonance angiography (TOF-MRA) in the continuous assessment of the status of a tissue-engineered vascular graft in rat. As a model graft, a single connective tubular tissue (diameter; 1.5 mm), prepared by embedding the silicone rod (diameter; 1.5 mm) into a subcutaneous pouch of a rat for 2 weeks an in vivo tissue-engineering, was used. The graft was implanted in the abdominal aorta (diameter; 1.3 mm) of the rat by end-to-end anastomosis. Repeated TOF-MRA imaging of the graft obtained over a 3-month follow-up period after implantation made it possible to evaluate the patency of the graft, both simply and noninvasively. It also permitted visualization of the connected abdominal aorta and renal and common iliac arteries having smaller caliber (diameter; less than I mm). In addition, the degree of the stenosis or aneurysm could also be detected. 3-Tesla MRA allowed the simplified and noninvasive assessment of the status on the vascular graft, including the formation of a stenosis or aneurysm, in the same rat at different times, which will be contributing to enhance the development of tissue-engineered vascular grafts even with small caliber. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 92B: 156-160, 2010



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