A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Up-regulation of host cell genes during interferon-gamma-induced persistent Chlamydia pneumoniae infection in HL cells

Julkaisun tekijät: Mannonen L, Nikula T, Haveri A, Reinikainen A, Vuola JM, Lahesmaa R, Puolakkainen M
Julkaisuvuosi: 2007
Journal: Journal of Infectious Diseases
Tietokannassa oleva lehden nimi: The Journal of infectious diseases
Lehden akronyymi: J Infect Dis
Volyymi: 195
Julkaisunumero: 2
Sivujen määrä: 8
ISSN: 0022-1899

As a step toward understanding the role played by host gene expression in the development and pathogenesis of persistent Chlamydia pneumoniae infection, modulation of the host-cell transcriptional response during interferon (IFN)- gamma -induced persistent C. pneumoniae infection of HL cells was examined by a cDNA array and then selectively by a real-time quantitative reverse transcription-polymerase chain reaction. We identified 9 host cell genes whose transcription was consistently altered during IFN- gamma -induced persistent C. pneumoniae infection. The strongest up-regulation of persistent infection, compared with controls (active infection and IFN- gamma ) was identified for insulin-like growth factor-binding protein 6, IFN-stimulated protein 15 kDa, cyclin D1, and interleukin-7 receptor genes. These results suggest that, during persistent infection, C. pneumoniae reprograms the host transcriptional machinery that regulates a variety of cellular processes, including adhesion, regulation of the cell cycle, growth, and inflammatory response, all of which might play important roles in the pathogenesis of persistent C. pneumoniae infection.

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Last updated on 2019-21-08 at 23:13