A1 Journal article – refereed
Asymmetric Synthesis of Five-Membered Spiropyrazolones via N-Heterocyclic Carbene (NHC)-Catalyzed [3+2] Annulations




List of Authors: Li S, Wang L, Chauhan P, Peuronen A, Rissanen K, Enders D
Publisher: GEORG THIEME VERLAG KG
Publication year: 2017
Journal: Synthesis: stuttgart
Journal name in source: SYNTHESIS-STUTTGART
Journal acronym: SYNTHESIS-STUTTGART
Volume number: 49
Issue number: 8
Number of pages: 8
ISSN: 0039-7881

Abstract
A new synthetic strategy for the asymmetric synthesis of five-membered spiropyrazolones via N-heterocyclic carbene-catalyzed [3+2] annulations employing enals and unsaturated pyrazolones as substrates has been developed. The new protocol allows the flexible variation of all four substituents of the pharmaceutically important spiropyrazolones in moderate to very good yields and in most cases with excellent diastereoselectivities and good to excellent enantioselectivities.

Last updated on 2019-20-07 at 09:18