A1 Journal article – refereed
OPTIMIZATION OF H-2 O-15-CBF METHOD FOR HIGHER SIGNAL-TO-NOISE RATIO




List of Authors: KANNO I, IIDA H, MIURA S
Publisher: KLUWER ACADEMIC PUBL
Publication year: 1991
Journal name in source: MEDICAL PROGRESS THROUGH TECHNOLOGY
Journal acronym: MED PROG TECHNOL
Volume number: 17
Number of pages: 4
ISSN: 0047-6552

Abstract
We described theoretical principle and data analysis for PET study using intravenous (H2O)-O-15 for measurement of cerebral blood flow (CBF) with emphasis on stimulation study for psychophysiological test. In order to improve signal-to-noise (S/N) ratio in CBF images, we optimized the scan procedures and data analysis. We determined optimal scantime of autoradiographic image to provide minimum S/N ratio as to 90 through 120 sec. Increase of full-width at half-maximum (FWHM) of smoothing filter did reduce the image noise (standard deviation, SD) more rapidly than the partial volume effect. Phantom experiment showed a tendency that a larger FWHM provided a higher statistical t-value.

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