Refereed journal article or data article (A1)
Evaluation of different mathematical models for diffusion-weighted imaging of normal prostate and prostate cancer using high b-values: A repeatability study
List of Authors: Jambor Ivan, Merisaari Harri, Taimen Pekka, Boström Peter, Minn Heikki, Pesola Marko, Aronen Hannu Juhani
Publication year: 2015
Journal: Magnetic Resonance in Medicine
Volume number: 73
Issue number: 5
Start page: 1988
End page: 1998
Number of pages: 11
ISSN: 0740-3194
DOI: http://dx.doi.org/10.1002/mrm.25323
URL: http://onlinelibrary.wiley.com/doi/10.1002/mrm.25323/abstract
PURPOSE:
To evaluate monoexponential, stretched exponential, kurtosis, and biexponential models for diffusion-weighted imaging (DWI) of normal prostate and prostate cancer (PCa), using b-values up to 2000 s/mm2 , in terms of fitting quality and repeatability.
METHODS:
Eight healthy volunteers and 16 PCa patients underwent a total of four repeated 3T DWI examinations using 16 and 12 b-values, respectively. The highest b-value was 2000 s/mm2 . The normalized mean signal intensities of regions of interest, placed in normal tissue and PCa using anatomical images and prostatectomy sections, were fitted using the four models. The fitting quality was evaluated using Akaike information criteria and F-ratio. Repeatability of the fitted parameters was evaluated using intraclass correlation coefficient ICC(3,1).
RESULTS:
The biexponential model provided the best fit to normal prostate and PCa DWI data. The parameters of the monoexponential, kurtosis, and stretched exponential (with the exception of the α parameter) models had higher ICC(3,1) values compared with the biexponential model. The kurtosis model provided a better fit to DWI data of normal prostate and PCa than the monoexponential model, whereas these models had comparable reliability and repeatability based on ICC(3,1) values.
CONCLUSION:
Considering the model fit and repeatability, the kurtosis model seems to be the preferred model for characterization of normal prostate and PCa DWI using b-values up to 2000 s/mm2