A1 Refereed original research article in a scientific journal
Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions
Authors: Dongfei Liu, Katriina Lipponen, Peng Quan, Xiaocao Wan, Hongbo Zhang, Ermei Mäkilä, Jarno Salonen, Risto Kostiainen, Jouni Hirvonen, Tapio Kotiaho, Hélder A. Santos
Publisher: AMER CHEMICAL SOC
Publication year: 2018
Journal: ACS Biomaterials Science and Engineering
Journal name in source: ACS BIOMATERIALS SCIENCE & ENGINEERING
Journal acronym: ACS BIOMATER SCI ENG
Volume: 4
Issue: 7
First page : 2308
Last page: 2313
Number of pages: 11
ISSN: 2373-9878
DOI: https://doi.org/10.1021/acsbiomaterials.8b00343
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/35414755
By exploiting its porous structure and high loading capacity, porous silicon (PSi) is a promising biomaterial to fabricate protocells and biomimetic reactors. Here, we have evaluated the impact of physicochemical properties of PSi particles [thermally oxidized PSi, TOPSi; annealed TOPSi, AnnTOPSi; (3-aminopropyl) triethoxysilane functionalized thermally carbonized PSi, APTES-TCPSi; and thermally hydrocarbonized PSi, THCPSi] on their surface interactions with different phospholipids. All of the four phospholipids were similarly adsorbed by the surface of PSi particles, except for TOPSi. Among four PSi particles, TOPSi with hydrophilic surface and smaller pore size showed the weakest adsorption toward phosphatidylcholines. By increasing the pore size from roughly 12.5 to 18.0 nm (TOPSi vs AnnTOPSi), the quantity of phosphatidylcholines adsorbed by TOPSi was enhanced to the same level of hydrophilic APTES-TCPSi and hydrophobic THCPSi. The 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) exhibited the highest release ratio of phospholipids from all four PSi particles, and phosphatidylserine (DPPS) showed the lowest release ratio of phospholipids from PSi particles, except for TOPSi, which adsorbed less phospholipids due to the small pore size. There is consistency in the release extent of phospholipids from PSi particles and the isosteric heat of adsorption. Overall, our study demonstrates the importance of pore size and surface chemistry of PSi particles as well as the structure of phospholipids on their interactions. The obtained information can be employed to guide the selection of PSi particles and phospholipids to fabricate highly ordered structures, for example, protocells, or biomimetic reactors.
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