A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
6-[18F]Fluoro-l-DOPA Uptake in the Rat Pancreas is Dependent on the Tracer Metabolism




Julkaisun tekijät: Kalliokoski T, Tuomela J, Haavisto L, Forsback S, Snellman A, Helin S, Gronroos TJ, Solin O, Haaparanta-Solin M
Kustantaja: SPRINGER
Julkaisuvuosi: 2014
Journal: Molecular Imaging and Biology
Tietokannassa oleva lehden nimi: MOLECULAR IMAGING AND BIOLOGY
Lehden akronyymi: MOL IMAGING BIOL
Volyymi: 16
Sivujen määrä: 9
ISSN: 1536-1632

Tiivistelmä


Altering the metabolism of [F-18]FDOPA by using various enzymatic inhibitors increased the radioactivity uptake and changed the radiometabolic profile in the pancreas allowing better discrimination between pancreas and surrounding tissues of rat. However, these manipulations did not separate islets from the exocrine pancreas. Elucidating the metabolic behavior of [F-18]FDOPA provides a biochemical foundation of PET imaging of the rat pancreas.


Last updated on 2019-29-01 at 20:04