A1 Journal article – refereed
6-[18F]Fluoro-l-DOPA Uptake in the Rat Pancreas is Dependent on the Tracer Metabolism




List of Authors: Kalliokoski T, Tuomela J, Haavisto L, Forsback S, Snellman A, Helin S, Gronroos TJ, Solin O, Haaparanta-Solin M
Publisher: SPRINGER
Publication year: 2014
Journal: Molecular Imaging and Biology
Journal name in source: MOLECULAR IMAGING AND BIOLOGY
Journal acronym: MOL IMAGING BIOL
Volume number: 16
Issue number: 3
Number of pages: 9
ISSN: 1536-1632

Abstract


Altering the metabolism of [F-18]FDOPA by using various enzymatic inhibitors increased the radioactivity uptake and changed the radiometabolic profile in the pancreas allowing better discrimination between pancreas and surrounding tissues of rat. However, these manipulations did not separate islets from the exocrine pancreas. Elucidating the metabolic behavior of [F-18]FDOPA provides a biochemical foundation of PET imaging of the rat pancreas.


Last updated on 2019-09-09 at 22:14