A1 Refereed original research article in a scientific journal
Global Distribution of Human Protoparvoviruses
Authors: Elina Väisänen, Ushanandini Mohanraj, Paula M. Kinnunen1, Pikka Jokelainen, Haider Al-Hello, Ali M. Barakat, Mohammadreza Sadeghi, Farid A. Jalilian, Amir Majlesi, Moses Masika, Dufton Mwaengo, Omu Anzala, Eric Delwart, Olli Vapalahti, Klaus Hedman, Maria Söderlund-Venermo
Publisher: CENTERS DISEASE CONTROL
Publication year: 2018
Journal: Emerging Infectious Diseases
Journal name in source: EMERGING INFECTIOUS DISEASES
Journal acronym: EMERG INFECT DIS
Volume: 24
Issue: 7
First page : 1292
Last page: 1299
Number of pages: 8
ISSN: 1080-6040
DOI: https://doi.org/10.3201/eid2407.172128
Web address : https://wwwnc.cdc.gov/eid/article/24/7/17-2128_article
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/32503927
Development of next-generation sequencing and metagenomics has revolutionized detection of novel viruses. Among these viruses are 3 human protoparvoviruses: bufavirus, tusavirus, and cutavirus. These viruses have been detected in feces of children with diarrhea. In addition, cutavirus has been detected in skin biopsy specimens of cutaneous T-cell lymphoma patients in France and in 1 melanoma patient in Denmark. We studied seroprevalences of IgG against bufavirus, tusavirus, and cutavirus in various populations (n = 840), and found a striking geographic difference in prevalence of bufavirus IgG. Although prevalence was low in adult populations in Finland (1.9%) and the United States (3.6%), bufavirus IgG was highly prevalent in populations in Iraq (84.8%), Iran (56.1%), and Kenya (72.3%). Conversely, cutavirus IgG showed evenly low prevalences (0%-5.6%) in all cohorts, and tusavirus IgG was not detected. These results provide new insights on the global distribution and endemic areas of protoparvoviruses.
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