A1 Journal article – refereed
SYNTHESIS OF 7-SUBSTITUTED 3-beta-D-RIBOFURANOSYL-3H-IMIDAZO[2,1-i]PURINES




List of Authors: Karskela T, Klika KD, Lonnberg H
Publisher: INST ORGANIC CHEM AND BIOCHEM
Publication year: 2011
Journal: Collection of Czechoslovak Chemical Communications
Journal name in source: COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
Journal acronym: COLLECT CZECH CHEM C
Number in series: 8
Volume number: 76
Issue number: 8
ISSN: 0010-0765

Abstract
A method for the synthesis of 7-substituted 3-beta-D-ribofuranosyl-3H-imidazo[2,1-i]purines has been devised whereby compounds were prepared in a few steps from a common intermediate, 3-(2',3'-O-isopropylidene-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine-7-carbaldehyde, obtained from the reaction of 2',3'-O-isopropylideneadenosine with bromomalonaldehyde. The formyl group of the carbaldehyde was subsequently reductively aminated and the resulting secondary amines were then further derivatized either by acylation, lactamization or reductive alkylation.


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Last updated on 2019-21-08 at 23:35