A1 Journal article – refereed
Occurrence and Features of Childhood Myocarditis: A Nationwide Study in Finland.

List of Authors: Anita Arola, Essi Pikkarainen, Jussi OT Sipilä, Jouni Pykäri, Päivi Rautava, Ville Kytö
Publisher: Oxford : Wiley-Blackwell
Publication year: 2017
Journal: Journal of the American Heart Association
Journal name in source: Journal of the American Heart Association
Journal acronym: J Am Heart Assoc
Volume number: 6
Issue number: 11
Number of pages: 7
ISSN: 2047-9980


Background Epidemiology of myocarditis in childhood is largely unknown. Men are known to have a higher incidence of myocarditis than women in adults aged <50 years, but whether this is true by sex in pediatric age groups is unknown. We set out to study the occurrence and potential sex differences of myocarditis in a general pediatric population.

Methods and Results Data of all hospital admissions with myocarditis in Finland occurring in patients aged ≤15 years from 2004 to 2014 were collected from a mandatory nationwide registry. All patients with myocarditis as a primary, secondary, or tertiary cause of admission were included. Total and age‐ and sex‐specific incidence rates were calculated using corresponding population data. There were 213 admissions with myocarditis in pediatric patients. Myocarditis was the primary cause of admission in 86%. The overall incidence rate of myocarditis was 1.95/100 000 person‐years. Of all patients, 77% were boys, but sex differences in incidence rates were age‐dependent. In children aged 0 to 5 years, there was no sex difference in the occurrence of myocarditis. Boys aged 6 to 10 years had a higher incidence rate compared with girls (72% boys; incidence rate ratio: 2.46; 95% confidence interval, 1.03–5.89; P=0.04). Sex difference further increased in children aged 11 to 15 years (80% boys; incidence rate ratio: 3.5; 95% confidence interval, 2.68–5.67; P<0.0001).

Conclusions Myocarditis leading to hospital admission is relatively uncommon in children, but occurrence of myocarditis increases with age. There is no sex difference in the risk of myocarditis during the first 6 years of life, but boys have a significantly higher risk at ages 6 to 15 years.

Last updated on 2019-21-08 at 19:56

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