A1 Journal article – refereed
New World, but not Old World, monkeys carry several genes encoding beta-microseminoprotein




List of Authors: Makinen M, Valtonen-Andre V, Lundwall A
Publisher: BLACKWELL SCIENCE LTD
Publication year: 1999
Journal: European Journal of Biochemistry
Journal name in source: EUROPEAN JOURNAL OF BIOCHEMISTRY
Journal acronym: EUR J BIOCHEM
Volume number: 264
Issue number: 2
ISSN: 0014-2956

Abstract
It was shown by Southern hybridization that cotton-top tamarin and common marmoset, New World monkeys, carry three or more genes encoding beta-microseminoprotein, also known as PSP94 In contrast, the genomes of Old World monkeys, as represented by rhesus macaque and sacred baboon, contain a single gene. Clones containing three different genes encoding beta-microseminoprotein were isolated from a cotton-top tamarin genomic library. They carry two complete genes of four exons and a third gene lacking the first exon. The structure suggests that the three genes are functionally active and give rise to transcripts that are approximate to 86% similar in sequence. By sequencing one gene in full, it was shown that the introns carry an excess of interspersed repeats, on average 29% of the introns consist of Alu repeats. A phylogenetic analysis demonstrated that the genes probably arose in New World monkeys after the separation from Old World primates.

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