Refereed journal article or data article (A1)
α-Melanocyte-stimulating hormone regulates vascular NO availability and protects against endothelial dysfunction
List of Authors: Petteri Rinne, Wendy Nordlund, Ilkka Heinonen, Anna-Maija Penttinen, Antti Saraste, Suvi T. Ruohonen, Satu Mäkelä, Laura Vähätalo, Katja Kaipio, Minying Cai, Victor J. Hruby, Saku Ruohonen, Eriika Savontaus
Publisher: OXFORD UNIV PRESS
Publication year: 2013
Journal: Cardiovascular Research
Journal name in source: CARDIOVASCULAR RESEARCH
Journal acronym: Cardiovasc Res
Number in series: 2
Volume number: 97
Issue number: 2
Start page: 360
End page: 368
Number of pages: 9
ISSN: 0008-6363
eISSN: 1755-3245
DOI: http://dx.doi.org/10.1093/cvr/cvs335
The present study identifies -MSH and endothelial MC1 receptors as a new signalling pathway contributing to the regulation of NO availability and vascular function. These findings suggest applicability of -MSH analogues for therapeutic use in pathological conditions that are characterized by vascular dysfunction.