A1 Journal article – refereed
Antibacterial properties of nitric oxide-releasing porous silicon nanoparticles




List of Authors: Kafshgari MH, Delalat B, Harding FJ, Cavallaro A, Makila E, Salonen J, Vasilev K, Voelcker NH
Publisher: Royal Society of Chemistry
Publication year: 2016
Journal name in source: JOURNAL OF MATERIALS CHEMISTRY B
Journal acronym: J MATER CHEM B
Volume number: 4
Issue number: 11
Number of pages: 8
ISSN: 2050-750X
eISSN: 2050-7518

Abstract


In this study, the antibacterial efficacy of NO-releasing porous silicon nanoparticles (pSiNPs) is reported. NO-releasing pSiNPs were produced via the conjugation of S-nitrosothiol (SNO) and S-nitrosoglutathione (GSNO) donors to the nanoparticle surfaces. The release of the conjugated NO caused by the decomposition of the conjugated SNO and GSNO was boosted in the presence of ascorbic acid. The released NO was bactericidal to Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli), and eliminated bacterial growth within 2 h of incubation without compromising the viability of mammalian cells. These results demonstrate the advantages of NO-releasing pSiNPs for antibacterial applications, for example, in chronic wound treatment.



Last updated on 2019-21-08 at 22:35