A1 Journal article – refereed
Effect of toremifene on the activity of NK-cells in NZB/NZW mice




List of Authors: Wärri A., Kangas L.
Publication year: 1990
Journal name in source: Journal of Steroid Biochemistry
Volume number: 36
Issue number: 3
Number of pages: 3
ISSN: 0022-4731

Abstract
The effect of toremifene on NK-cells isolated from the spleen of NZB/NZW mice was studied in comparison to tamoxifen and estradiol. Unlike estradiol but like tamoxifen, toremifene did not influence the activity of NK-cells. Low doses (0.1 and 10.0 mg/kg) of toremifene did not suppress, but a high dose of toremifene and tamoxifen (50 mg/kg for 6 weeks) suppressed the stimulating effect of human interferon alpha on the cells. © 1990.

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